Document Detail

Arterial blood gas tensions during exercise in neonatal lambs.
MedLine Citation:
PMID:  10563444     Owner:  NLM     Status:  MEDLINE    
At the onset of exercise, adult animals increase ventilation to match or exceed the metabolic requirement. This error-free regulation of arterial blood gas tensions may be attributable to 'adaptive feed-forward control'--respiratory control based on experience gained in infancy. This hypothesis predicts that neonates exhibit hypercapnia at the onset of exercise. To test this prediction, seven lambs were exercised on a treadmill at 0.8 m/sec at the ages of 2-5 days, and again at 9-12 days. Arterial blood samples were drawn pre-exercise and at 0.5, 1, 2, 5, 7 and 10 min of exercise. Seven adult sheep were similarly tested for comparison. The lambs had significantly higher arterial CO2 tensions (PaCO2) and lower arterial O2 tensions (PaO2) than adult sheep both at rest and during exercise. Nonetheless, the lambs maintained PaCO2 at or below the resting level throughout exercise. PaO2 rose significantly during exercise in the sheep and lambs. The results do not support the hypothesis since hypercapnia was not observed in the exercising neonatal lambs.
P L Entin; R E Rawson
Related Documents :
25190304 - Mobile selected ion flow tube mass spectrometry (sift-ms) devices and their use for pol...
8293064 - The accent method of voice therapy: effect of accentuations on fo, spl, and airflow.
6407294 - Respiratory gas analysis during exercise as a noninvasive measure of lactate concentrat...
935694 - Role of the carotid chemoreceptors in the hyperpnea of exercise in the cat.
24589644 - Skeletal muscle troponin as a novel biomarker to enhance assessment of the impact of st...
12190654 - Sensitization to horse hair, symptoms and lung function in grooms.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  117     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-9     Citation Subset:  IM    
Department of Medicine, University of California, San Diego, La Jolla 92093-0623, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Animals, Newborn
Blood Gas Analysis
Body Temperature
Carbon Dioxide / blood
Hypercapnia / physiopathology
Oxygen / blood
Oxygen Consumption
Physical Conditioning, Animal / physiology*
Pulmonary Ventilation / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of gas density on experimentally obstructed ventilation during acute hypoxia.
Next Document:  Relaxant action produced by sodium nitroprusside in guinea-pig tracheal muscle.