Document Detail

Arterial blood gas tensions during exercise in neonatal lambs.
MedLine Citation:
PMID:  10563444     Owner:  NLM     Status:  MEDLINE    
At the onset of exercise, adult animals increase ventilation to match or exceed the metabolic requirement. This error-free regulation of arterial blood gas tensions may be attributable to 'adaptive feed-forward control'--respiratory control based on experience gained in infancy. This hypothesis predicts that neonates exhibit hypercapnia at the onset of exercise. To test this prediction, seven lambs were exercised on a treadmill at 0.8 m/sec at the ages of 2-5 days, and again at 9-12 days. Arterial blood samples were drawn pre-exercise and at 0.5, 1, 2, 5, 7 and 10 min of exercise. Seven adult sheep were similarly tested for comparison. The lambs had significantly higher arterial CO2 tensions (PaCO2) and lower arterial O2 tensions (PaO2) than adult sheep both at rest and during exercise. Nonetheless, the lambs maintained PaCO2 at or below the resting level throughout exercise. PaO2 rose significantly during exercise in the sheep and lambs. The results do not support the hypothesis since hypercapnia was not observed in the exercising neonatal lambs.
P L Entin; R E Rawson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  117     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-9     Citation Subset:  IM    
Department of Medicine, University of California, San Diego, La Jolla 92093-0623, USA.
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MeSH Terms
Age Factors
Animals, Newborn
Blood Gas Analysis
Body Temperature
Carbon Dioxide / blood
Hypercapnia / physiopathology
Oxygen / blood
Oxygen Consumption
Physical Conditioning, Animal / physiology*
Pulmonary Ventilation / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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