Document Detail


Arterial baroreflex modulation influences postural sway.
MedLine Citation:
PMID:  21184247     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Although considered mainly a random function, postural sway is influenced by physiological factors such as respiration. A direct effect of the autonomic nervous system (ANS) on posture has never been demonstrated. To test this hypothesis, we used a pure motion-independent autonomic stimulus (neck suction) to modulate the carotid baroreceptors on a broad frequency range, distinct from that of respiration. METHODS: Thirteen healthy subjects (age 26 ± 5 years) were studied upright, eyes closed, and on a force platform during controlled breathing (15 breath/min, 0.25 Hz), with and without stimulation of arterial baroreceptors by sinusoidal neck suction (0 to -30 mmHg pressure) at different frequencies (0.05, 0.10, 0.125, 0.15, 0.175, 0.20, 0.30 Hz), for eight periods lasting 2 min each. The increase in sway, R-R interval and blood pressure induced at each stimulation frequency was measured by spectral analysis. RESULTS: With neck suction, we observed a significant (p < 0.05) increase in oscillations synchronous in the R-R interval (from 0.10 to 0.20 Hz), systolic and diastolic blood pressure (from 0.05 to 0.15 Hz) and sway (from 0.10 to 0.30 Hz in both the antero-posterior and medio-lateral planes). Changes were greater in the left than in the right foot. CONCLUSION: Our study shows that postural sway is modulated by the ANS and is influenced by phasic stimulation of the arterial (carotid) baroreceptors. Our findings have potentially important clinical implications in the development of treatment strategies for pathological conditions in which alterations in posture and autonomic function coexist and could be mutually influenced.
Authors:
Luciano Bernardi; Monica Bissa; Giacomo Debarbieri; Abhishek Bharadwaj; Alessia Nicotra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-24
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  -     ISSN:  1619-1560     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Clinica Medica 2, University of Pavia, IRCCS S.Matteo, 27100, Pavia, Italy, lbern1ps@unipv.it.
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