Document Detail


Arterial baroreflex function in conscious rats.
MedLine Citation:
PMID:  12147187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial baroreflex (ABR) is a very important mechanism in the regulation of cardiovascular activities. As ABR function is largely inhibited by anesthesia, its measurement in conscious animal becomes important. The present review summarizes the works concerning ABR function in conscious rats completed in our department in the last 10 years. Firstly, a new method was established to measure arterial baroreflex-blood pressure control (ABR-BP). ABR-BP and baroreflex sensitivity measured with classic method are two different parts of the ABR function. Secondly, it was proposed that ABR function predicted the end-organ damage in hypertension. Thirdly, interruption of ABR induced severe end-organ damages. Increased blood pressure variability (BPV) and activation of renin angiotensin system were involved in the mechanisms underlying organ damages in sinoaortic denervation (SAD) rats. Fourthly, we propose that amelioration of ABR function may serve as a new strategy for improving the prognosis of cardiovascular diseases. Ketanserin improved the impaired ABR function in SHR. Finally, the possibility to develop a strain of rats with spontaneous deficiency on ABR function is mentioned.
Authors:
Ding-Feng Su; Chao-Yu Miao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  23     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-30     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  673-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China. dfsu@citiz.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / innervation
Baroreflex / physiology*
Blood Pressure / physiology*
Denervation
Hypertension / physiopathology*
Ketanserin
Rats
Rats, Inbred SHR
Sinoatrial Node / innervation
Chemical
Reg. No./Substance:
74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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