Document Detail

Arterial baroreceptor resetting: contributions of chronic and acute processes.
MedLine Citation:
PMID:  2805444     Owner:  NLM     Status:  MEDLINE    
1. Pressure threshold (Pth) and suprathreshold pressure sensitivity (Sth) are important measures of the pressure-discharge characteristics of arterial baroreceptors. An in vitro preparation of the rat aortic arch-aortic nerve has been used to assess the influence of extracellular ion concentration, distensibility, smooth muscle activation and rapid resetting on single fibre baroreceptor discharge. 2. Changes in extracellular cations alter Pth and Sth in a reciprocal manner, suggesting that these two properties share common excitatory mechanisms probably at the level of membrane ion conductance channels. 3. During normal development and ageing in normotensive rats, Pth and blood pressure are fairly constant even during periods of greatly changing aortic distensibility. Sth increases progressively to maturity and then decreases somewhat with advanced age. 4. During hypertension, changes in distensibility in spontaneously hypertensive rats do not account for changes in Pth and Sth. 5. The capacity of arterial baroreceptors to rapidly reset during acute changes in the conditioning mean arterial pressure is not altered by chronic resetting, decreases in distensibility or by differences in the initial Pth or Sth of individual baroreceptors. 6. Within the maximal physiological or pathophysiological range, the prevailing or conditioning mean arterial pressure appears to be the most potent modulator of arterial baroreceptor discharge.
M C Andresen; M Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology. Supplement     Volume:  15     ISSN:  0143-9294     ISO Abbreviation:  Clin Exp Pharmacol Physiol Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7611484     Medline TA:  Clin Exp Pharmacol Physiol Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19-30     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Aging / physiology
Arteries / physiology*
Blood Pressure / drug effects
Calcium / pharmacology
Hypertension / physiopathology
Pressoreceptors / physiology*
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
Grant Support
Reg. No./Substance:

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