| Arterial baroreceptor resetting: contributions of chronic and acute processes. | |
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MedLine Citation:
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PMID: 2805444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Pressure threshold (Pth) and suprathreshold pressure sensitivity (Sth) are important measures of the pressure-discharge characteristics of arterial baroreceptors. An in vitro preparation of the rat aortic arch-aortic nerve has been used to assess the influence of extracellular ion concentration, distensibility, smooth muscle activation and rapid resetting on single fibre baroreceptor discharge. 2. Changes in extracellular cations alter Pth and Sth in a reciprocal manner, suggesting that these two properties share common excitatory mechanisms probably at the level of membrane ion conductance channels. 3. During normal development and ageing in normotensive rats, Pth and blood pressure are fairly constant even during periods of greatly changing aortic distensibility. Sth increases progressively to maturity and then decreases somewhat with advanced age. 4. During hypertension, changes in distensibility in spontaneously hypertensive rats do not account for changes in Pth and Sth. 5. The capacity of arterial baroreceptors to rapidly reset during acute changes in the conditioning mean arterial pressure is not altered by chronic resetting, decreases in distensibility or by differences in the initial Pth or Sth of individual baroreceptors. 6. Within the maximal physiological or pathophysiological range, the prevailing or conditioning mean arterial pressure appears to be the most potent modulator of arterial baroreceptor discharge. |
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Authors:
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M C Andresen; M Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology. Supplement Volume: 15 ISSN: 0143-9294 ISO Abbreviation: Clin Exp Pharmacol Physiol Suppl Publication Date: 1989 |
Date Detail:
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Created Date: 1989-12-19 Completed Date: 1989-12-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7611484 Medline TA: Clin Exp Pharmacol Physiol Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 19-30 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77550. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Arteries / physiology* Blood Pressure / drug effects Calcium / pharmacology Hypertension / physiopathology Male Pressoreceptors / physiology* Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY |
| Grant Support | |
ID/Acronym/Agency:
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HL28698/HL/NHLBI NIH HHS; HL33436/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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