Document Detail


Arterial and antihypertensive effects of nitrendipine: a double-blind comparison versus placebo.
MedLine Citation:
PMID:  1282585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial effects evaluated by carotid-femoral, brachial-radial, and femoral-tibial pulse wave velocity and antihypertensive effect evaluated by 24-h ambulatory blood pressure (BP) monitoring were measured in 17 hypertensive patients before and 24 h after once-daily nitrendipine (20 mg) administration. After a 15-day placebo period, a double-blind study of nitrendipine versus placebo was performed for 1 month. After nitrendipine dosing, BP measured by sphygmomanometer 24 h after the last drug intake showed a significant decrease as compared with the pretreatment period. Ambulatory BP mean values were also significantly decreased for systolic and diastolic BP (SBP, DBP). This decrease predominated during the day but was observed nocturnally only after 6 a.m. Twenty-four hours after the last tablet intake of nitrendipine, carotid-femoral and brachial-radial pulse wave velocities were significantly reduced, whereas femoral-tibial wave velocity was unchanged, indicating that markers of arterial rigidity might be substantially modified and that the modifications were partly unrelated to BP changes. The results provide evidence that in hypertensive subjects nitrendipine 20 mg given once daily for 1 month produces an arterial effect for 24 h, in association with BP reduction.
Authors:
R Asmar; A Benetos; M Brahimi; K Chaouche; M Safar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  858-63     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Hypertension Research Center, Hôpital Broussais, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arteries / drug effects*
Blood Pressure / drug effects
Blood Pressure Determination
Double-Blind Method
Female
Heart Rate / drug effects*
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Nitrendipine / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
39562-70-4/Nitrendipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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