| Arterial aging--hemodynamic changes and therapeutic options. | |
| | |
MedLine Citation:
|
PMID: 20657613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Arterial aging can be attributed to two different pathophysiological changes--increase in arterial stiffness and disturbed wave reflections. The capacity of the aorta to absorb the force exerted by the left ventricular ejection and dampen pulsatile flow becomes diminished with advancing age, owing to the progressive hardening of the arterial wall. These changes contribute to increase blood pressure, mainly systolic blood pressure and pulse pressure, which can trigger cardiovascular events. Understanding the pulsatile arterial hemodynamics that elevate cardiovascular risk has led to the use of pharmacological therapies, which prevent arterial stiffness and reduce wave reflections, and improve cardiovascular morbidity and mortality. Antifibrotic agents, such as those that block the renin-angiotensin-aldosterone pathway, are often given in association with diuretics, calcium-channel blockers, or both, but not with standard beta-blockers. Consistent reductions in cardiovascular outcomes obtained using these agents can be predicted through noninvasive measurements of central systolic blood pressure and pulse pressure. |
| | |
Authors:
|
Michel E Safar |
Related Documents
:
|
2864173 - Spontaneous multiple unit activity from the preoptic nucleus and changes in blood press... 1360793 - Electrocardiographic changes during acute treatment of hypertensive emergencies with so... 2668463 - Ambulatory blood pressure measurement and antihypertensive therapy. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Nature reviews. Cardiology Volume: 7 ISSN: 1759-5010 ISO Abbreviation: Nat Rev Cardiol Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-26 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101500075 Medline TA: Nat Rev Cardiol Country: England |
Other Details:
|
Languages: eng Pagination: 442-9 Citation Subset: IM |
Affiliation:
|
Diagnosis Center, Hôpital Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris Cedex 04, France michel.safar@htd.aphp.fr. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Aged Aging* / pathology Arteries / drug effects, pathology, physiopathology* Cardiovascular Agents / therapeutic use Cardiovascular Diseases / pathology, physiopathology*, therapy Female Hemodynamics* / drug effects Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of two aberrant transcripts derived from a hybridoma with amplification of functional...
Next Document: Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia.