| Is Arterial Wall-Strain Stiffening an Additional Process Responsible for Atherosclerosis in Coronary Bifurcations? : in vivo Study Based on Dynamic CT and MRI. | |
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MedLine Citation:
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PMID: 21685261 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Coronary bifurcations represent specific regions of the arterial tree that are susceptible to atherosclerotic lesions. While the effects of vessel compliance, curvature, pulsatile blood flow and cardiac motion on coronary endothelial shear stress have been widely explored, the effects of myocardial contraction on arterial wall stress/strain (WS/S) and vessel stiffness distributions remain unclear. Local increase of vessel stiffness resulting from wall-strain stiffening phenomenon - a local process due to the nonlinear mechanical properties of the arterial wall - may be critical in the development of atherosclerotic lesions. Therefore, the aim of this study was to quantify WS/S and stiffness in the coronary bifurcations and to investigate correlations with plaque sites. Anatomic coronary geometry and cardiac motion were generated based on both computer tomography and magnetic resonance imaging examinations of eight patients with minimal coronary disease. Computational structural analyses using finite element method were subsequently performed and spatial luminal arterial wall stretch (LW(stretch)) and stiffness (LW(stiff)) distributions in the left main coronary bifurcations were calculated. Our results show that all plaque sites were concomitantly subject to high LW(Stretch) and high LW(Stiff), with mean amplitudes 34.7±1.6% and 442.4±113.0 kPa, respectively. The mean LW(Stiff) amplitude was found slightly greater at the plaque sites on the left main coronary (mean value, 482.2±88.1 kPa) as compared to those computed on the left anterior descending and left circumflex coronaries (416.3±61.5 kPa and 428.7±181.8 kPa, respectively). These finding suggests that local wall stiffness plays a role in the initiation of atherosclerotic lesions. |
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Authors:
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Jacques Ohayon; Ahmed M Gharib; Alberto Garcia; Julie Heroux; Saami K Yazdani; Mauro Malve; Philippe Tracqui; Miguel Angel Martinez; Manuel Doblare; Gerard Finet; Roderic I Pettigrew |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-17 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1UJF and University of Savoie. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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