Document Detail


Is arterial wall-strain stiffening an additional process responsible for atherosclerosis in coronary bifurcations?: an in vivo study based on dynamic CT and MRI.
MedLine Citation:
PMID:  21685261     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary bifurcations represent specific regions of the arterial tree that are susceptible to atherosclerotic lesions. While the effects of vessel compliance, curvature, pulsatile blood flow, and cardiac motion on coronary endothelial shear stress have been widely explored, the effects of myocardial contraction on arterial wall stress/strain (WS/S) and vessel stiffness distributions remain unclear. Local increase of vessel stiffness resulting from wall-strain stiffening phenomenon (a local process due to the nonlinear mechanical properties of the arterial wall) may be critical in the development of atherosclerotic lesions. Therefore, the aim of this study was to quantify WS/S and stiffness in coronary bifurcations and to investigate correlations with plaque sites. Anatomic coronary geometry and cardiac motion were generated based on both computed tomography and MRI examinations of eight patients with minimal coronary disease. Computational structural analyses using the finite element method were subsequently performed, and spatial luminal arterial wall stretch (LW(Stretch)) and stiffness (LW(Stiff)) distributions in the left main coronary bifurcations were calculated. Our results show that all plaque sites were concomitantly subject to high LW(Stretch) and high LW(Stiff), with mean amplitudes of 34.7 ± 1.6% and 442.4 ± 113.0 kPa, respectively. The mean LW(Stiff) amplitude was found slightly greater at the plaque sites on the left main coronary artery (mean value: 482.2 ± 88.1 kPa) compared with those computed on the left anterior descending and left circumflex coronary arteries (416.3 ± 61.5 and 428.7 ± 181.8 kPa, respectively). These findings suggest that local wall stiffness plays a role in the initiation of atherosclerotic lesions.
Authors:
Jacques Ohayon; Ahmed M Gharib; Alberto Garcia; Julie Heroux; Saami K Yazdani; Mauro Malvè; Philippe Tracqui; Miguel-Angel Martinez; Manuel Doblare; Gérard Finet; Roderic I Pettigrew
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-17
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  301     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-31     Completed Date:  2011-11-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1097-106     Citation Subset:  IM    
Affiliation:
Laboratory of Integrative Cardiovascular Imaging Science, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. jacques.ohayon@imag.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biomechanics
Coronary Angiography / methods*
Coronary Artery Disease / diagnosis*,  pathology,  physiopathology,  radiography
Coronary Vessels / pathology*,  physiopathology
Elasticity
Female
Finite Element Analysis
Hemodynamics
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging*
Male
Middle Aged
Models, Cardiovascular
Myocardial Contraction*
Nonlinear Dynamics
Plaque, Atherosclerotic / diagnosis*,  pathology,  physiopathology,  radiography
Predictive Value of Tests
Stress, Mechanical
Time Factors
Tomography, X-Ray Computed*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maize opaque5 encodes monogalactosyldiacylglycerol synthase and specifically affects galactolipids n...
Next Document:  Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells.