Document Detail

Arterial stiffness, physical function, and functional limitation: the Whitehall II Study.
MedLine Citation:
PMID:  21444833     Owner:  NLM     Status:  MEDLINE    
Arterial stiffness has been proposed as an indicator of vascular aging. We aimed to examine this concept by analyzing associations of arterial stiffness with age, subjective and objective measures of physical functioning, and self-reported functional limitation. We measured aortic pulse wave velocity by applanation tonometry among 5392 men and women aged 55 to 78 years. Arterial stiffness was strongly associated with age (mean difference [SE] per decade: men, 1.37 m/s [0.06 m/s]; women: 1.39 m/s [0.10 m/s]). This association was robust to individual and combined adjustment for pulse pressure, mean arterial pressure, antihypertensive treatment, and chronic disease. Participants took an 8.00-ft (2.44-m) walking speed test, a spirometry lung function test, and completed health functioning and (instrumental) activities of daily living questionnaires. Associations of stiffness and blood pressure with physical function scores scaled to SD of 10 were compared. One-SD higher stiffness was associated with lower walking speed (coefficient [95% CI]: -0.96 [-1.29 to -0.64] m/s) and physical component summary score (-0.91 [-1.21 to -0.60]) and poorer lung function (-1.23 [-1.53 to -0.92] L) adjusted for age, sex, and ethnic group. Pulse pressure and mean arterial pressure were linked inversely only with lung function. Associations of stiffness with functional limitation were robust to multiple adjustment, including pulse pressure and chronic disease. In conclusion, the concept of vascular aging is reinforced by the observation that arterial stiffness is a robust correlate of physical functioning and functional limitation in early old age. The nature of the link between arterial stiffness and quality of life in older people merits attention.
Eric J Brunner; Martin J Shipley; Daniel R Witte; Archana Singh-Manoux; Annie R Britton; Adam G Tabak; Carmel M McEniery; Ian B Wilkinson; Mika Kivimaki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2011-03-28
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-21     Completed Date:  2011-06-30     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1003-9     Citation Subset:  IM    
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MeSH Terms
Activities of Daily Living
Age Factors
Aging / physiology*
Aorta / physiopathology*
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Longitudinal Studies
Middle Aged
Motor Activity / physiology
Pulsatile Flow / physiology
Vascular Resistance / physiology
Grant Support
FS/07/001/21990//British Heart Foundation; G0902037//Medical Research Council; HL36310/HL/NHLBI NIH HHS; HS06516/HS/AHRQ HHS; PG/11/63/29011//British Heart Foundation; R01 AG013196/AG/NIA NIH HHS; R01AG013196/AG/NIA NIH HHS; R01AG034454/AG/NIA NIH HHS; //British Heart Foundation; //Department of Health; //Medical Research Council

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