| Arterial stiffness, physical function, and functional limitation: the Whitehall II Study. | |
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MedLine Citation:
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PMID: 21444833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial stiffness has been proposed as an indicator of vascular aging. We aimed to examine this concept by analyzing associations of arterial stiffness with age, subjective and objective measures of physical functioning, and self-reported functional limitation. We measured aortic pulse wave velocity by applanation tonometry among 5392 men and women aged 55 to 78 years. Arterial stiffness was strongly associated with age (mean difference [SE] per decade: men, 1.37 m/s [0.06 m/s]; women: 1.39 m/s [0.10 m/s]). This association was robust to individual and combined adjustment for pulse pressure, mean arterial pressure, antihypertensive treatment, and chronic disease. Participants took an 8.00-ft (2.44-m) walking speed test, a spirometry lung function test, and completed health functioning and (instrumental) activities of daily living questionnaires. Associations of stiffness and blood pressure with physical function scores scaled to SD of 10 were compared. One-SD higher stiffness was associated with lower walking speed (coefficient [95% CI]: -0.96 [-1.29 to -0.64] m/s) and physical component summary score (-0.91 [-1.21 to -0.60]) and poorer lung function (-1.23 [-1.53 to -0.92] L) adjusted for age, sex, and ethnic group. Pulse pressure and mean arterial pressure were linked inversely only with lung function. Associations of stiffness with functional limitation were robust to multiple adjustment, including pulse pressure and chronic disease. In conclusion, the concept of vascular aging is reinforced by the observation that arterial stiffness is a robust correlate of physical functioning and functional limitation in early old age. The nature of the link between arterial stiffness and quality of life in older people merits attention. |
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Authors:
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Eric J Brunner; Martin J Shipley; Daniel R Witte; Archana Singh-Manoux; Annie R Britton; Adam G Tabak; Carmel M McEniery; Ian B Wilkinson; Mika Kivimaki |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2011-03-28 |
Journal Detail:
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Title: Hypertension Volume: 57 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-21 Completed Date: 2011-06-30 Revised Date: 2013-05-06 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1003-9 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK. e.brunner@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Age Factors Aged Aging / physiology* Aorta / physiopathology* Blood Flow Velocity / physiology Blood Pressure / physiology* Female Humans Longitudinal Studies Male Middle Aged Motor Activity / physiology Pulsatile Flow / physiology Questionnaires Vascular Resistance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL36310/HL/NHLBI NIH HHS; HS06516/HS/AHRQ HHS; R01 AG013196/AG/NIA NIH HHS; R01 AG013196-14/AG/NIA NIH HHS; R01 AG013196-16/AG/NIA NIH HHS; R01AG013196/AG/NIA NIH HHS; R01AG034454/AG/NIA NIH HHS; //British Heart Foundation; //Department of Health; //Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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