| Arterial Stiffness Is the Independent Factor of Left Ventricular Hypertrophy Determined by Electrocardiogram. | |
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MedLine Citation:
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PMID: 22270392 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Arterial stiffness may contribute to left ventricular hypertrophy (LVH). This study was conducted to evaluate the independent factor of LVH and the quantification of LVH by electrocardiogram (ECG) to predict the degree of aortic stiffness using brachial-ankle pulse wave velocity (baPWV) in subjects with hypertension. MATERIALS AND METHODS: A total of 984 consecutive patients who were diagnosed as having essential hypertension were entered into the study. baPWV determination, ECG and blood sampling were performed after a 12-hour overnight fast. LVH was diagnosed using electrocardiography; Romhilt-Estes point score was subsequently calculated. Participants were separated into LVH and non-LVH groups. Additional factors associated with LVH were examined using multivariate analyses. RESULTS: The non-LVH groups were younger (P = 0.001), had less men (P = 0.001), lower systolic and diastolic blood pressure and pulse pressure (P < 0.001 for each) and lower baPWV (P < 0.001). Stepwise multiple logistic regression analysis demonstrated that sex, age, systolic blood pressure and baPWV are independent factors. Using a baPWV value of 1825 cm/sec, the area under the receiver operating characteristic curve was 0.644 and the highest discriminating sensitivity and specificity were 60% and 65%, respectively. CONCLUSION: Aortic stiffness may be related to electrocardiographically determined LVH in patients with hypertension. Thus, stiffening of large arteries, together with increased systolic blood pressure, seems to significantly contribute to the pathogenesis of LVH. Quantification of LVH by ECG can also predict the degree of aortic stiffness. |
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Authors:
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Chang-Min Chung; Yu-Sheng Lin; Chi-Ming Chu; Shih-Tai Chang; Hui-Wen Cheng; Teng-Yao Yang; Ju-Feng Hsiao; Kuo-Li Pan; Jen-Te Hsu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Division of Cardiology (C-MC, Y-SL, S-TC, H-WC, T-YY, J-FH, K-LP, J-TH), Chiayi Chang Gung Memorial Hospital; Chiayi School (C-MC, Y-SL, S-TC, H-WC, T-YY, J-FH, K-LP, J-TH), Chang Gung Institute of Technology, Chai Yi Hsien, Taiwan; Chang Gung University College of Medicine (C-MC, Y-SL, S-TC, H-WC, T-YY, J-FH, K-LP, J-TH), Tao-Yuan, Taiwan, Section of Health Informatics (C-MC), Institute of Public Health, National Defense Medical Center and University, Taipei, Taiwan. |
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