Document Detail

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease.
MedLine Citation:
PMID:  20940711     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease.
METHODS: We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age ± s.d. 73.6 ± 2.9 years, 48% men, 39% black).
RESULTS: In mixed-effects models adjusted for demographics, each s.d. (396 cm/s) higher PWV was associated with 0.015 (s.e. 0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P < 0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with 0.028 (s.e. 0.010) m/s slower gait speed at baseline and throughout the study period (P < 0.01).
CONCLUSIONS: These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.
Nora L Watson; Kim Sutton-Tyrrell; Ada O Youk; Robert M Boudreau; Rachel H Mackey; Eleanor M Simonsick; Caterina Rosano; Susan E Hardy; B Gwen Windham; Tamara B Harris; Samer S Najjar; Edward G Lakatta; Hal H Atkinson; Karen C Johnson; Douglas C Bauer; Anne B Newman; Anne B Nemwan;
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2010-09-09
Journal Detail:
Title:  American journal of hypertension     Volume:  24     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  2011-02-11     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-5     Citation Subset:  IM    
Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Arteries / physiopathology*
Blood Pressure
Peripheral Arterial Disease / physiopathology*
Pulsatile Flow
Grant Support
N01 AG062101/AG/NIA NIH HHS; N01 AG062103/AG/NIA NIH HHS; N01 AG062106/AG/NIA NIH HHS; N01-AG-6-2101/AG/NIA NIH HHS; N01-AG-6-2103/AG/NIA NIH HHS; N01-AG-6-2106/AG/NIA NIH HHS; P30 AG024827/AG/NIA NIH HHS
Erratum In:
Am J Hypertens. 2011 Feb;24(2):248
Note: Nemwan, Anne B [corrected to Newman, Anne B]

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