| Arterial Grafts Protect the Native Coronary Vessels From Atherosclerotic Disease Progression. | |
| | |
MedLine Citation:
|
PMID: 22727250 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: We sought to examine the effect of different conduits on the progression of atherosclerosis in previously revascularized coronary territories. METHODS: Between 1995 and 2010, 4,960 patients were discharged alive after primary isolated coronary artery bypass grafting (CABG) with a left internal thoracic artery (LITA) conduit and additional conduits as needed: radial artery (RA) or saphenous vein graft (SVG), or both. Seven hundred seventy-two patients had coronary angiography for recurrent symptoms an average of 5.5 ± 3.5 years after CABG (range, 0.1-16 years). Cumulative graft patency and disease progression in the native vessels was estimated by the Kaplan-Meier survival method. The log-rank test was used to assess differences of disease progression per territory between different types of conduits. RESULTS: Kaplan-Meier-estimated 1-, 5-, and 10-year overall disease progression in territories with patent LITAs was 0.01%, 4%, and 8%, respectively; with patent RA grafts, it was 0.01%, 6%, and 11%, respectively (log-rank test, p = 0.157); and with patent SVGs it was 3%, 19%, and 43%, respectively (log-rank test; p < 0.0001). Disease progression in grafted native coronary arteries in the anterior territory with patent LITA-to-left anterior descending (LAD) artery was 8%, and with patent RA grafts versus patent SVGs to the diagonal branches of LAD artery was 10% and 40%, respectively (log-rank test; p < 0.0001). Disease progression in grafted native coronary arteries to the lateral territory with a patent RA graft was 11% versus 50% with a patent SVG (log-rank test; p < 0.0001). CONCLUSIONS: RA and LITA grafting has a strong protective effect against progression of native coronary artery disease in previously grafted vessels. Multiple arterial grafting may improve long-term survival by preventing progression of atherosclerosis in the native coronary vessels. |
| | |
Authors:
|
Kamellia R Dimitrova; Darryl M Hoffman; Charles M Geller; Gabriela Dincheva; Wilson Ko; Robert F Tranbaugh |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-22 |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: - ISSN: 1552-6259 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiac Surgery, Beth Israel Medical Center, New York, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Late Outcomes for Surgical Repair of Supravalvar Aortic Stenosis.
Next Document: Older age is associated with similar quality of life and physical function compared to younger age d...