Document Detail

Arterial Endothelium-Derived Hyperpolarisation: Potential Role in Pregnancy Adaptations and Complications.
MedLine Citation:
PMID:  23188131     Owner:  NLM     Status:  Publisher    
ABSTRACT: Pregnancy encompasses substantial changes in vascular function in order to accommodate dramatic increases in blood volume and uteroplacental blood flow to the growing fetus. Despite increased hemodynamics, decreased peripheral resistance results in a reduction in mean arterial blood pressure. Vascular tone, and hence peripheral resistance, is determined by a delicate balance of constrictor and dilator capacities. In the normal physiological response to pregnancy, EDH has been shown to be a major contributor; both endothelial-derived hyperpolarisation (EDH) and nitric oxide (NO) are predominantly involved in providing an increased vascular capacity for vasodilation. The ability of EDH and NO to adequately accommodate increased blood volume is tested in pathological states such as placental insufficiency or diabetes and both EDH and NO-dependent mechanisms appear to be impacted in these situations. Pregnancy complications also impact on the cardiovascular health of the offspring. In adult offspring born from complicated pregnancies, the data suggest that EDH mechanisms are largely maintained while NO is commonly reduced. A diversity of EDH mechanisms may be useful in providing many targets for potential therapeutic avenues for compromised pregnancies; however, further research delineating the mechanisms of EDH and the interactions of NO and EDH, in normal and pathological pregnancies is required.
Jude S Morton; Sandra T Davidge
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-22
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Canada 2Department of Physiology, University of Alberta, Edmonton, Canada 3Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Canada.
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