Document Detail


Artemisinin suppresses sympathetic hyperinnervation following myocardial infarction via anti-inflammatory effects.
MedLine Citation:
PMID:  22922993     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammation plays an important role in sympathetic remodeling after myocardial infarction (MI), and the inhibition of inflammation has therapeutic benefits that could alleviate the progression of sympathetic remodeling. Recent studies have indicated that the antimalarial agent artemisinin has the ability to inhibit inflammation. In this study, the inhibitory effects of artemisinin on the production of proinflammatory mediators and the number of macrophages were investigated 4 weeks after MI. Our results show that artemisinin significantly inhibited IL-1β and TNF-α protein expression and the infiltration of macrophages. Artemisinin significantly decreased the protein expression of NGF, GAP43, and TH compared with the control group, which was related to sympathetic nerve remodeling. Interestingly, a clear positive correlation was observed between the expression of NGF and GAP43 in our study, and a similar correlation was revealed between NGF and TH. In addition, the densities of both GAP-43- and TH-immunoreactive nerves in the peri-infarct zone were significantly attenuated by artemisinin treatment. Our results suggest that artemisinin is able to inhibit sympathetic remodeling after MI, possibly through an anti-inflammatory effect. The data provide direct evidence of the potential application of artemisinin for the treatment of sympathetic remodeling after MI.
Authors:
Yongwei Gu; Xi Wang; Gang Wu; Xin Wang; Hong Cao; Yanhong Tang; Congxin Huang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-26
Journal Detail:
Title:  Journal of molecular histology     Volume:  -     ISSN:  1567-2387     ISO Abbreviation:  J. Mol. Histol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101193653     Medline TA:  J Mol Histol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, People's Republic of China.
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