| Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. | |
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MedLine Citation:
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PMID: 8801435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease. |
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Authors:
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S R Meshnick; T E Taylor; S Kamchonwongpaisan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Microbiological reviews Volume: 60 ISSN: 0146-0749 ISO Abbreviation: Microbiol. Rev. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-09-30 Completed Date: 1996-09-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7806086 Medline TA: Microbiol Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 301-15 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA. meshnick@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimalarials / metabolism, pharmacology, therapeutic use* Artemisinins* Clinical Trials as Topic Drug Resistance Humans Malaria / drug therapy* Malaria, Falciparum / drug therapy* Peroxides / metabolism, pharmacology, therapeutic use*, toxicity Plasmodium falciparum / drug effects Sesquiterpenes / metabolism, pharmacology, therapeutic use*, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 0/Peroxides; 0/Sesquiterpenes; 63968-64-9/artemisinine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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