| Arsenite-induced apoptosis is prevented by selenite in A375 cell line. | |
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MedLine Citation:
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PMID: 20390378 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Arsenic trioxide induces apoptosis and clinical remission in patients diagnosed with acute promyelocytic leukemia. The human malignant melanoma A375 cells were treated with NaAsO2 (0.1–130 μM) and also treated with combined 10 μM NaAsO2 and 10 μM Na2SeO3. NaAsO2 arrested cell growth in the G1 phase and induced apoptosis in a concentration- and time-dependent manner. In contrast, administration of Na2SeO3 antagonized the cell growth inhibition and apoptosis induced by NaAsO2. The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. |
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Authors:
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Zhi-Fang Wang; Xiong Guo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 140 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 7-17 Citation Subset: IM |
Affiliation:
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Faculty of Public Health, College of Medicine, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an Jiaotong University, Xi’an, Shaanxi, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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