Document Detail


Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function.
MedLine Citation:
PMID:  22465848     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Arsenic trioxide (ATO) is widely used in tumor treatment, but excessive arsenic exposure can have adverse health effects. This study was to examine the association between ATO treatment and bone remodeling. The effects of ATO on osteoblast function were investigated in primary cell cultures and in an in vivo study in rats. Sprague-Dawley rats (n=30) were randomly assigned to 3 groups which were injected intraperitoneally with saline or 5 or 10mg/kg of ATO for 4weeks. In cell culture, ATO decreased osteoblast mineralization by decreasing alkaline phosphatase (ALP) expression and this effect was prevented by co-addition of inorganic phosphate (Pi). Moreover, levels of mRNAs for the transcription factors runt-related transcription factor 2 (Runx2) and osterix, the osteoblast osteogenic gene osteocalcin, and the adherence molecule vascular cell adhesion molecule-1 (VCAM-1) were decreased by ATO. Levels of mRNAs for the cytokine IL-6 were also decreased, whereas GM-CSF mRNA levels were increased. Similar effects of ATO on osteoblasts were seen in in vivo experiments in the rat. Moreover, decreases of bone turnover markers of osteocalcin, Procollagen type I N-terminal propeptide (PINP), and C-terminal cross-linked telopeptide (CTX) as well as bone mineral density (BMD) and trabecular bone volume of femur were observed in ATO-treated rats. These results suggest that ATO interferes with bone remodeling mostly through changes in osteoblast differentiation and function.
Authors:
Yu-Chen Hu; Hsiao-Ling Cheng; Bau-Shan Hsieh; Li-Wen Huang; Tzu-Ching Huang; Kee-Lung Chang
Related Documents :
20205238 - Polyester copolymer scaffolds enhance expression of bone markers in osteoblast-like cells.
19921838 - Molecular mechanism of hesperetin-7-o-glucuronide, the main circulating metabolite of h...
8156938 - Parathyroid hormone-related protein as a prohormone: posttranslational processing and r...
24577408 - Histamine contributes to tissue remodeling via periostin expression.
18559608 - Interaction of cisplatin with the human organic cation transporter 2.
16616718 - The transcription factor cdx2 regulates the intestine-specific expression of human pept...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Bone     Volume:  -     ISSN:  1873-2763     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Iron status and fibroblast growth factor-23 in Gambian children.
Next Document:  Chronic exposure to methylphenidate impairs appendicular bone quality in young rats.