| Arsenic speciation transported through the placenta from mother mice to their newborn pups. | |
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MedLine Citation:
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PMID: 16458287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The primary goal of the present study was to confirm the arsenic species that can be transferred from the mother to the bodies of newborn pups through the placenta and the speciated arsenic distribution in the liver and brain of newborn mice after gestational maternal exposure to inorganic arsenic (iAs). Mother mice were exposed to iAsIII and iAsV in drinking water during gestation. The livers and brains of the mother mice and their newborn pups were taken. Contents of iAs, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and trimethylarsenic (TMA) compound were detected using the HG-AAS method. Contents of iAs, MMA, and DMA in the liver of mother mice increased with the concentration of arsenite or arsenate in their drinking water. However, only DMA increased with the concentration of arsenate or arsenite in the drinking water in the brain of mother mice. On the other hand, contents of both iAs and DMA in the liver and brain of newborn mice increased with the concentration of arsenate or arsenite administered to their mother orally. Contents of arsenic species in the liver and brain of both mother mice and their newborn pups were significantly lower in the 10 ppm iAsV group than in the 10 ppm iAsIII group. Ratios of iAs or DMA levels between the brain and the liver of newborn mice were larger than 1, whereas those in mother mice were much smaller than 1. iAs taken from drinking water was distributed and metabolized mainly in the liver of mother mice. iAsIII in low levels may be taken up and metabolized easily in the liver compared to iAsV. Both iAs and DMA are transferred from the mother through the placenta and cross the immature blood-brain barrier (BBB) easily. Compared to that in the liver of newborn mice, DMA as an organic metabolite is prevalent in brain, a lipidic organ, if the BBB is not matured enough to prevent it from entering the brain. |
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Authors:
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Yaping Jin; Shuhua Xi; Xin Li; Chunwei Lu; Gexin Li; Yuanyuan Xu; Chunqing Qu; Yuhong Niu; Guifan Sun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-02 |
Journal Detail:
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Title: Environmental research Volume: 101 ISSN: 0013-9351 ISO Abbreviation: Environ. Res. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-02 Completed Date: 2006-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 349-55 Citation Subset: IM |
Affiliation:
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Department of Environmental and Occupational Health, College of Public Health, China Medical University, Shenyang, Liaoning 110001, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Arsenic / metabolism Arsenicals / administration & dosage, metabolism*, pharmacokinetics Blood-Brain Barrier / metabolism Brain / metabolism* Brain Chemistry Dose-Response Relationship, Drug Drinking Female Liver / chemistry, metabolism* Maternal-Fetal Exchange* Mice Placenta / metabolism* Pregnancy Prenatal Exposure Delayed Effects Random Allocation Tissue Distribution Water Pollutants, Chemical / metabolism, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Arsenicals; 0/Water Pollutants, Chemical; 7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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