Document Detail

Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan.
MedLine Citation:
PMID:  17173945     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern. This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders. METHOD: There were 871 subjects (488 women and 383 men) and among them 372 were diagnosed as having hypertension based on a positive history or measured systolic blood pressure >or=140 mm Hg and/or diastolic blood pressure >or=90 mm Hg. Urinary arsenic species were determined by high-performance liquid chromatography-hydride generator and atomic absorption spectrometry. Primary arsenic methylation index [PMI, defined as monomethylarsonic acid (MMA(V)) divided by (As(III)+As(V))] and secondary arsenic methylation index (SMI, defined as dimethylarsinic acid divided by MMA(V)) were used as indicators for arsenic methylation capability. RESULTS: The level of urinary arsenic was still significantly correlated with cumulative arsenic exposure (CAE) calculated from a questionnaire interview (p=0.02) even after the residents stopped drinking the artesian well water for 2-3 decades. Hypertensive subjects had higher percentages of MMA(V) and lower SMI than subjects without hypertension. However, subjects having CAE >0 mg/L-year had higher hypertension risk than those who had CAE=0 mg/L-year disregard a high or low methylation index. CONCLUSION: Inefficient arsenic methylation ability may be related with hypertension risk.
Yung-Kai Huang; Chin-Hsiao Tseng; Ya-Li Huang; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei Hsueh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-28
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  218     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-42     Citation Subset:  IM    
Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan.
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MeSH Terms
Age Factors
Alcohol Drinking / adverse effects,  epidemiology
Arsenic / blood,  metabolism*,  urine
Arsenic Poisoning / epidemiology*,  genetics,  metabolism*
Arsenicals / blood,  metabolism,  urine
Blood Pressure / physiology
Cholesterol / blood
Endemic Diseases
Hypertension / chemically induced,  epidemiology*,  metabolism*
Lipids / blood
Middle Aged
Risk Factors
Sex Factors
Smoking / epidemiology
Spectrophotometry, Atomic
Taiwan / epidemiology
Triglycerides / blood
Reg. No./Substance:
0/Arsenicals; 0/Lipids; 0/Triglycerides; 124-58-3/monomethylarsonic acid; 57-88-5/Cholesterol; 7440-38-2/Arsenic

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