| Arsenic methylation capability, heme oxygenase-1 and NADPH quinone oxidoreductase-1 genetic polymorphisms and the stage and grade of urothelial carcinomas. | |
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MedLine Citation:
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PMID: 18587252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Arsenic exposure is associated with an increased risk of urothelial carcinoma (UC). To explore the distribution of the arsenic methylation capability in patients with different stages and grades of UCs, 100 UC cases were recruited between September 2002 and May 2004 for this study. METHODS: Urinary arsenic species, including inorganic arsenic (As(III) + As(V)), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), were determined with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Determining the percentages of various arsenic species among the total urinary arsenic amount assessed the arsenic methylation capability. The primary methylation index (PMI) was defined as the ratio between MMA and inorganic arsenic. The secondary methylation index (SMI) was determined as the ratio between DMA and MMA. RESULTS: Differential effects of the arsenic methylation capability were found among patients with different stages of UCs; however, none was found among different grades. CONCLUSION: A significantly different distribution of the HO-1 genotype was found in subjects with different-stage UCs; however, it was not related to the NAD(P)H:quinone oxidoreductase 1 genotype. |
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Authors:
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Steven K Huang; Allen Wen-Hsiang Chiu; Yeong-Shiau Pu; Yung-Kai Huang; Chi-Jung Chung; Hui-Ju Tsai; Mo-Hsiung Yang; Chien-Jen Chen; Yu-Mei Hsueh |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-27 |
Journal Detail:
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Title: Urologia internationalis Volume: 80 ISSN: 1423-0399 ISO Abbreviation: Urol. Int. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-06-30 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: Switzerland |
Other Details:
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Languages: eng Pagination: 405-12 Citation Subset: IM |
Copyright Information:
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2008 S. Karger AG, Basel. |
Affiliation:
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Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Analysis of Variance Arsenic / adverse effects* Arsenic Poisoning / complications Carcinoma, Transitional Cell / chemically induced, epidemiology, genetics, pathology* Cohort Studies DNA Methylation Environmental Exposure / adverse effects* Female Humans Incidence Male Middle Aged NADH, NADPH Oxidoreductases / genetics*, metabolism Neoplasm Staging Polymorphism, Genetic* Probability Prognosis Risk Assessment Survival Analysis Taiwan / epidemiology Urinary Bladder Neoplasms / chemically induced, epidemiology, genetics, pathology* |
| Chemical | |
Reg. No./Substance:
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7440-38-2/Arsenic; EC 1.6.-/NADH, NADPH Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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