Document Detail


Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.
MedLine Citation:
PMID:  17929749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arsenic is a naturally occurring metalloid, ubiquitously present in the environment in both organic and inorganic forms. Arsenic contamination of groundwater in the West Bengal basin in India is unfolding as one of the worst natural geoenvironmental disaster to date. Chronic exposure of humans to high concentration of arsenic in drinking water is associated with skin lesions, peripheral vascular disease, hypertension, Blackfoot disease and high risk of cancer The underlying mechanism of toxicity includes the interaction with the sulphydryl groups and the generation of reactive oxygen species leading to oxidative stress. Chelation therapy with chelating agents like British Anti Lewisite (BAL), sodium 2,3-dimercaptopropane 1-sulfonate (DMPS), meso 2,3 dimercaptosuccinic acid (DMSA) etc., is considered to be the best known treatment against arsenic poisoning. The treatment with these chelating agents however is compromised with certain serious drawbacks/side effects. The studies show that supplementation of antioxidants along with a chelating agent prove to be a better treatment regimen. This review attempts to provide the readers with a comprehensive account of recent developments in the research on arsenic poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects.
Authors:
S J S Flora; Smrati Bhadauria; G M Kannan; Nutan Singh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of environmental biology / Academy of Environmental Biology, India     Volume:  28     ISSN:  0254-8704     ISO Abbreviation:  J Environ Biol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-10-12     Completed Date:  2008-02-26     Revised Date:  2009-03-09    
Medline Journal Info:
Nlm Unique ID:  8300544     Medline TA:  J Environ Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  333-47     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior-474 002, India. sjsflora@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / therapeutic use
Animals
Antioxidants / therapeutic use*
Arsenic Poisoning / drug therapy*
Ascorbic Acid / therapeutic use
Chelating Agents / therapeutic use*
Chelation Therapy
Dimercaprol / therapeutic use
Drug Therapy, Combination
Environmental Pollutants / poisoning*
Humans
Melatonin / therapeutic use
Oxidative Stress / drug effects
Plant Extracts / therapeutic use
Selenium / therapeutic use
Succimer / analogs & derivatives,  therapeutic use
Taurine / therapeutic use
Thioctic Acid / therapeutic use
Vitamin E / therapeutic use
Zinc / therapeutic use
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Chelating Agents; 0/Environmental Pollutants; 0/Plant Extracts; 0/monoisoamyl-2,3-dimercaptosuccinate; 107-35-7/Taurine; 1406-18-4/Vitamin E; 304-55-2/Succimer; 50-81-7/Ascorbic Acid; 59-52-9/Dimercaprol; 616-91-1/Acetylcysteine; 62-46-4/Thioctic Acid; 73-31-4/Melatonin; 7440-66-6/Zinc; 7782-49-2/Selenium

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