| Arsenic trioxide inhibits cholangiocarcinoma cell growth and induces apoptosis. | |
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MedLine Citation:
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PMID: 20012722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arsenic trioxide (As(2)O(3)), an ingredient in many traditional Chinese medicines, has drawn broad attention due to its therapeutic effects on a variety of cancers, including some solid tumors. However, the effects of As(2)O(3) on cholangiocarcinoma have not been reported. In the present study, we demonstrate for the first time that clinically obtainable concentrations of As(2)O(3) inhibit cell growth and induce apoptosis in human cholangiocarcinoma SK-ChA-1 cells. As(2)O(3)-induced apoptosis was partially inhibited by caspase inhibitor and accompanied by changes in the expression of Bcl-2 family proteins, decrease of mitochondrial membrane potential (MMP), release of cytochrome C from mitochondria, activation of caspase-3, caspase-9, and cleavage of poly (ADP-ribose) polymerase (PARP). Thus As(2)O(3) induces apoptosis in SK-ChA-1 cells via mitochondria-mediated, caspases-dependent pathways. As(2)O(3) inhibition of Akt phosphorylation may contribute to As(2)O(3)-mediated cholangiocarcinoma cell growth inhibition and apoptosis induction. |
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Authors:
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Fei Zhong; Shineng Zhang; Chunkui Shao; Jing Yang; Xiangyuan Wu |
Publication Detail:
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Type: Journal Article Date: 2009-12-12 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: 16 ISSN: 1532-2807 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 413-20 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Arsenicals / pharmacology* Bile Duct Neoplasms / pathology* Bile Ducts, Intrahepatic / pathology* Blotting, Western Cell Line, Tumor Cell Proliferation / drug effects* Cell Separation Cholangiocarcinoma / pathology* Flow Cytometry Humans Oxides / pharmacology* Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Arsenicals; 0/Oxides; 1327-53-3/arsenic trioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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