Document Detail


Arrhythmogenic remodelling of activation and repolarization in the failing human heart.
MedLine Citation:
PMID:  23104915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is a major cause of disability and death worldwide, and approximately half of heart failure-related deaths are sudden and presumably due to ventricular arrhythmias. Patients with heart failure have been shown to be at 6- to 9-fold increased risk of sudden cardiac death compared to the general population. (AHA. Heart Disease and Stroke Statistics-2003 Update. Heart and Stroke Facts. Dallas, TX: American Heart Association; 2002) Thus, electrophysiological remodelling associated with heart failure is a leading cause of disease mortality and has been a major investigational focus examined using many animal models of heart failure. While these studies have provided an important foundation for understanding the arrhythmogenic pathophysiology of heart failure, the need for corroborating studies conducted on human heart tissue has been increasingly recognized. Many human heart studies of conduction and repolarization remodelling have now been published and shed some light on important, potentially arrhythmogenic, changes in human heart failure. These studies are being conducted at multiple experimental scales from isolated cells to whole-tissue preparations and have provided insight into regulatory mechanisms such as decreased protein expression, alternative mRNA splicing of ion channel genes, and defective cellular trafficking. Further investigations of heart failure in the human myocardium will be essential for determining possible therapeutic targets to prevent arrhythmia in heart failure and for facilitating the translation of basic research findings to the clinical realm.
Authors:
Katherine M Holzem; Igor R Efimov
Related Documents :
23712465 - Treatment with atorvastatin is associated with a better prognosis in chronic heart fail...
24988275 - Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogen...
19131135 - Incidence and determinants of myocardial infarction following percutaneous coronary int...
23518395 - Morphological and functional changes in athletes' hearts during the competitive season.
21814655 - Patient information - holter monitors/event recorders.
23613225 - High osteopontin levels predict long-term outcome after stemi and primary percutaneous ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  14 Suppl 5     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-04-25     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  v50-v57     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Washington University in St Louis, One Brookings Drive, St Louis, MO 63130, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Animals
Arrhythmias, Cardiac / complications*,  physiopathology*
Computer Simulation
Heart Conduction System / physiopathology*
Heart Failure / etiology*,  physiopathology*
Humans
Models, Cardiovascular*
Grant Support
ID/Acronym/Agency:
R01 HL114395/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic engineering of somatic cells to study and improve cardiac function.
Next Document:  The role of action potential alternans in the initiation of atrial fibrillation in humans: a review ...