Document Detail

Arrhythmogenic mechanisms in human atrial and ventricular muscle fibers.
MedLine Citation:
PMID:  1511467     Owner:  NLM     Status:  MEDLINE    
Mechanisms which may lead to cardiac arrhythmias were studied in atrial and ventricular tissues from human hearts. In human atrial fibers, diastolic depolarization (DD) was consistently present, but did not induce spontaneous discharge. Epinephrine enhanced DD, could induce delayed afterdepolarizations (DADs) and (in combination with strophanthidin) trigger repetitive activity. The presence of DD modified the recovery of premature action potentials. Human ventricular fibers did not exhibit DD and were more resistant to Ca overload. It is concluded that in atrial tissues the presence of DD may not induce automatic arrhythmias, but it may influence conduction and re-entry rhythms. Cardioactive drugs may induce DADs and repetitive activity in the atria and less easily in the ventricles. The attainment of a threshold may be facilitated when DADs are superimposed.
T C Yeh; M Vassalle; C I Lin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology     Volume:  80     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-01     Completed Date:  1992-10-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM    
Department of Internal Medicine, National Defense Medical Center, Taipei, Taiwan, ROC.
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MeSH Terms
Action Potentials / drug effects
Arrhythmias, Cardiac / etiology*,  physiopathology
Atrial Function / physiology*
Epinephrine / pharmacology
Heart / anatomy & histology*
Heart Conduction System / drug effects,  physiology
Myocardial Contraction / physiology
Strophanthidin / pharmacology
Ventricular Function / physiology*
Reg. No./Substance:
51-43-4/Epinephrine; 66-28-4/Strophanthidin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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