| Arrhythmogenic effects of theophylline in human atrial tissue. | |
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MedLine Citation:
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PMID: 2445704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effects of theophylline on the transmembrane action potential and the contractile force of human atrial fibers obtained from the hearts of 15 patients, undergoing corrective open-heart surgery. Atrial fibers were perfused with Tyrode solution and driven electrically at a constant rate of 60 beats per min. Theophylline (0.1-1 mM) steepened the diastolic depolarization, increased the amplitude of oscillatory potential during diastole and facilitated the development of spontaneous slow response action potentials. These arrhythmogenic effects of theophylline were suppressed after diltiazem (0.1-0.3 microM) pretreatment. The present findings provide the electrophysiologic evidence that abnormal atrial automaticity as a result of triggered activity may be the underlying cause for atrial ectopic activity and multifocal atrial tachycardia in patients taking theophylline. |
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Authors:
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C I Lin; I N Chuang; K K Cheng; B N Chiang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cardiology Volume: 17 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-01-20 Completed Date: 1988-01-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 289-97 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, National Defense Medical Center, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arrhythmias, Cardiac / chemically induced* Calcium / metabolism Culture Techniques Electrocardiography* Heart Atria / drug effects* Heart Rate / drug effects Humans Ion Channels / drug effects Middle Aged Myocardial Contraction / drug effects Theophylline / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 58-55-9/Theophylline; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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