Document Detail

Arrhythmogenic difference between the left and right atria during rapid atrial activation in a canine model of atrial fibrillation.
MedLine Citation:
PMID:  17895563     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Continuous rapid atrial stimulation causes atrial remodeling, but little is known about the difference in the arrhythmogenicity of the left (LA) and right atria (RA). METHODS AND RESULTS: In 14 beagle dogs, continuous rapid pacing (400 beats/min) was delivered from the right (n=7) or left (n=7) atrial appendage (RAA or LAA) for 2 weeks. The atrial effective refractory period (ERP), ERP dispersion, and inducibility of atrial fibrillation (AF) were evaluated along the time course from 4 atrial sites: (1) RAA, (2) area close to the inferior vena cava (IVC), (3) Bachmann's bundle (BB) and (4) LA. The ERP exhibited progressive shortening at all sites, but the degree of shortening differed among them. In the RA stimulation group, ERP shortening was more prominent in the RAA and LA than in the IVC or BB. In contrast, in the LA stimulation group, ERP shortening was more prominent in the LA than in the other sites. As a result, ERP dispersion was larger in the LA stimulation group than in the RA stimulation group and the AF inducibility was higher in the LA stimulation group than in the RA stimulation group, especially at the LA site (p<0.05). CONCLUSION: LAA stimulation was more arrhythmogenic than RAA stimulation in this model. This result may partly explain the importance of premature contractions occurring from the pulmonary veins in clinical cases of AF.
Shinichi Niwano; Jisho Kojima; Hidehira Fukaya; Daisuke Sato; Masahiko Moriguchi; Hiroe Niwano; Yoshihiko Masaki; Tohru Izumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-26     Completed Date:  2007-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1629-35     Citation Subset:  IM    
Department of Cardio-angiology, Kitasato University School of Medicine, Sagamihara, Japan.
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MeSH Terms
Atrial Fibrillation / physiopathology*
Atrial Function / physiology
Disease Models, Animal
Electrophysiologic Techniques, Cardiac
Heart Atria / physiopathology*
Heart Conduction System / physiopathology
Heart Rate / physiology

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