Document Detail

Arrhythmias late after repair of tetralogy of fallot: a Japanese Multicenter Study.
MedLine Citation:
PMID:  14745146     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Arrhythmia is a major late complication in adults with repaired tetralogy of Fallot, although a large-scale study has not been carried out in Japan. METHODS AND RESULTS: A nationwide multicenter study with 512 operative survivors was performed. Actuarial survival rate at 30 years (maximum follow-up) was 98.4%. Fifty-four patients (10.5%) had clinically important arrhythmias, including 23 patients with bradycardia caused by sick sinus syndrome or atrioventricular block (AVB). A patient with complete AVB (CAVB) without pacemaker implantation (PMI) died later. Two patients had sustained ventricular tachycardia (VT) and syncope was reported in 18 patients with ventricular arrhythmias (VA). Atrial tachyarrhythmias were observed in 13 patients. Older age at operation was a risk factor for atrial fibrillation/flutter, longer postoperative survival duration for VA, and QRS duration >120 ms for VT. Perimembranous ventricular septal defect was related to CAVB. Right ventricular outflow patch was not a risk factor. Importantly, 60% of the subjects had QRS duration <120 ms. CONCLUSION: The prevalence of serious arrhythmias is low in Japanese TOF patients as compared with the results from Western countries. CAVB without PMI and VT are the major risk factors for late morbidity and mortality. The excellent result could be related to the narrow QRS after surgery.
Makoto Nakazawa; Tokuko Shinohara; Akihito Sasaki; Shigeyuki Echigo; Hideaki Kado; Koichiro Niwa; Kotaro Oyama; Michio Yokota; Mari Iwamoto; Norihide Fukushima; Masami Nagashima; Yoshihide Nakamura;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
The Heart Institute of Japan, Tokyo Women's Medical University, Japan.
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MeSH Terms
Arrhythmias, Cardiac / epidemiology,  etiology*,  mortality
Child, Preschool
Follow-Up Studies
Middle Aged
Risk Factors
Survival Analysis
Tetralogy of Fallot / complications,  mortality,  surgery*
Time Factors
Erratum In:
Circ J. 2004 Apr;68(4):403

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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