Document Detail

Arrhythmias after astemizole overdose.
MedLine Citation:
PMID:  8859918     Owner:  NLM     Status:  MEDLINE    
Astemizole, a relatively new H1 blocker, has been reported to cause ventricular arrhythmias in the poisoned patient. We present two cases of astemizole poisoning, one with asystole followed by ventricular fibrillation occurring 11 hours after ingestion treated with defibrillation and one with an isolated finding of a prolonged corrected QT interval. Electrocardiogram monitoring to detect conduction defects can identify patients at risk of developing life-threatening arrhythmias.
S M Heidemann; A P Sarnaik
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pediatric emergency care     Volume:  12     ISSN:  0749-5161     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-04-09     Completed Date:  1997-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-4     Citation Subset:  IM    
Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced*,  physiopathology,  therapy
Astemizole / poisoning*
Histamine H1 Antagonists / poisoning*
Reg. No./Substance:
0/Histamine H1 Antagonists; 68844-77-9/Astemizole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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