Document Detail

Arrhythmia mechanisms in the failing heart.
MedLine Citation:
PMID:  18684263     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart failure (HF) claims over 200,000 lives annually in the United States alone. Approximately 50% of these deaths are sudden and unexpected, and presumably the consequence of lethal ventricular tachyarrhythmias. Electrical remodeling that occurs at the cellular and tissue network levels predisposes patients with HF to malignant arrhythmias. Our limited understanding of fundamental arrhythmia mechanisms has hampered the development of effective treatment strategies for these patients.
METHODS AND CONCLUSIONS: In this review, we outline recent advances in our understanding of arrhythmia mechanisms in the failing heart, highlighting various aspects of remodeling of ion channels, calcium handling proteins, and gap junction-related molecules. As will be discussed, these changes promote the prolongation of the action potential, the enhancement of spatio-temporal gradients of repolarization, the formation of calcium-mediated triggers and conduction abnormalities, all of which combine to form an electrophysiological substrate that is ripe for the genesis of lethal arrhythmias and sudden cardiac death.
Hongwei Jin; Alexander R Lyon; Fadi G Akar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  31     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-10-30     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-56     Citation Subset:  IM    
Division of Cardiology, Cardiovascular Research Center, Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.
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MeSH Terms
Arrhythmias, Cardiac / complications*,  physiopathology*
Heart Conduction System / physiopathology*
Heart Failure / complications*,  physiopathology*
Models, Cardiovascular*

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