| Arrhythmia, heart rate variability, and antiepileptic drugs. | |
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MedLine Citation:
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PMID: 19909327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article reviews the clinical evidence for cardiac arrhythmias and alterations in heart rate variability (HRV) induced by antiepileptic drugs (AEDs). The medical literature was searched for cases with documented arrhythmias induced by AEDs at therapeutic doses, for systematic studies of the prevalence of arrhythmias related to AED therapy, and for studies on HRV in relation to AED treatment. Phenytoin has been associated predominantly with bradyarrhythmias, some of which were fatal. This has occurred almost exclusively with i.v. administration of the drug. Several reports demonstrate car-bamazepine's depressant effects on the cardiac conduction system. This has occurred mainly in the elderly or in otherwise predisposed patients. There were no reports of arrhythmias induced by other AEDs. Although information on HRV is scarce, treatment with carbamazepine appears to be associated with a decreased HRV. AED-induced cardiac arrhythmias are rare and occur mainly in patient populations different from those with a high incidence of sudden unexpected death. Further studies of HRV and AEDs are needed. |
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Authors:
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T Tomson; G Kennebäck |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Epilepsia Volume: 38 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 1997 Nov |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: S48-51 Citation Subset: IM |
Affiliation:
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Department of Clinical Neuroscience, Division of Neurology, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anticonvulsants / adverse effects*, therapeutic use Arrhythmias, Cardiac / chemically induced*, complications Death, Sudden, Cardiac / epidemiology*, etiology Electrocardiography Epilepsy / drug therapy*, mortality Female Heart Rate / drug effects, physiology* Humans Incidence Male Middle Aged Phenytoin / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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