Document Detail

Arrhythmia and right heart disease: from genetic basis to clinical practice.
MedLine Citation:
PMID:  20738941     Owner:  NLM     Status:  MEDLINE    
Historically, left ventricular cardiomyopathy and coronary heart disease have been regarded as the main causes of ventricular arrhythmia and sudden cardiac death. However, within last two decades, arrhythmias originating from the right ventricle have begun to attract the attention of the scientific world for a number of reasons. Ventricular arrhythmias originating from the right ventricle usually affect younger patients and can lead to sudden cardiac death. The pathophysiologic mechanism of these arrhythmias is not fully understood, which can leave room for a range of different interpretations. Moreover, the intriguing world of genetics is increasingly being drawn into the pathogenesis, diagnosis and prognosis of some of these arrhythmias. This review considers the pathogenesis, diagnosis and treatment of arrhythmogenic right ventricular cardiomyopathy or dysplasia (ARVD), Brugada syndrome, right ventricular outflow tract ventricular tachycardia, and arrhythmias in the right side of the heart due to congenital heart disease. In addition, because ventricular arrhythmias associated with right ventricular heart diseases such as Brugada syndrome and ARVD can explain up to 10-30% of sudden cardiac deaths in young adults in the general population and an even greater percentage in young athletes, this article contains a brief analysis of screening tests used before participation in sports, life-style modification, and treatment options for athletes affected by these conduction disorders.
Lucio Capulzini; Pedro Brugada; Josep Brugada; Ramon Brugada
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Revista española de cardiología     Volume:  63     ISSN:  1579-2242     ISO Abbreviation:  Rev Esp Cardiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404277     Medline TA:  Rev Esp Cardiol     Country:  Spain    
Other Details:
Languages:  eng; spa     Pagination:  963-83     Citation Subset:  IM    
Heart Rhythm Management Centre, UZ-Brussels-VUB, Bruselas, Bélgica.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis,  etiology*,  genetics,  therapy
Arrhythmogenic Right Ventricular Dysplasia / diagnosis,  etiology,  genetics,  therapy
Brugada Syndrome / diagnosis,  etiology,  genetics,  therapy
Ventricular Outflow Obstruction / complications

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