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Arresting Cancer Proliferation by Controlling Carbon Materials Surface Crystallinity without Generating Reactive Oxygen Species.
MedLine Citation:
PMID:  22609450     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study demonstrated that the surface crystallinity of carbon nanostructures is an additional independent factor that should be considered for the inhibition of cancer proliferation without activating reactive oxygen species (ROS). In addition, cytotoxic evaluation of both proliferating cancer cells and fully differentiated nerve cells (i.e. non-proliferative) showed selective cytotoxicity: single walled and highly crystalline carbon nanostructures aggressively inhibited the proliferation of glioma cancer cells, but exhibited no notable cytotoxicity effects on differentiated nerve cells. Although single wall carbon nanotubes have been shown to elicit potent pro-inflammatory responses by means of trigger ROS, our results demonstrated that highly crystalline carbon structures can be utilized as a selective anti-proliferative agent against brain tumor cells without increasing ROS level and without significant cytotoxic effects to adjacent nerve cells.
Authors:
Jungil Choi; Soyoung Lee; Wenping Wang; Soo-Hyun Hahm; Ye Sunhan; Tae-Hyun Nam; Sang-Hyun Kim; Sang Sookang; Dongwoo Khang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-17
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Department of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University, Jinju, 660-751, South Korea.
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