Document Detail


Arrest of flagellum morphogenesis with fibrous sheath immaturity of human spermatozoa.
MedLine Citation:
PMID:  16529576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Morphogenesis of the mammalian sperm flagellum is characterized by the assembly of axonemal and peri-axonemal structures. The incorporation of mitochondria into the flagellum results from complex cellular events, including flagellum compartmentalization and membrane and organelle reorganization. These events are striking in the annulus, which progressively relocates from the neck to the principal piece of the flagellum. This study presents a human sperm phenotype with failure of the annulus relocation, absence of mitochondrial sheath and a fibrous sheath at intermediate step of assembly. The sperm nucleus was fully condensed but with deep invaginations engulfing the acrosome. The distal pole of some mitochondria exhibited an unusual dense substance. This rare human sperm phenotype was found in a consanguineous patient, suggesting a genetic origin. These anomalies raise the question of the mechanisms that lead to impairment of both the annulus relocation and the deposit of proteins on the fibrous sheath during spermiogenesis.
Authors:
D Escalier
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Andrologia     Volume:  38     ISSN:  0303-4569     ISO Abbreviation:  Andrologia     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-13     Completed Date:  2006-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  IM    
Affiliation:
Andrology Department, University Paris XI, CHU Kremlin Bicêtre, France. denise.escalier@univ-paris5.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Humans
Male
Microscopy
Morphogenesis
Sperm Midpiece / pathology
Sperm Tail / pathology
Spermatogenesis
Spermatozoa / abnormalities*,  growth & development,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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