| Arrest of flagellum morphogenesis with fibrous sheath immaturity of human spermatozoa. | |
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MedLine Citation:
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PMID: 16529576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphogenesis of the mammalian sperm flagellum is characterized by the assembly of axonemal and peri-axonemal structures. The incorporation of mitochondria into the flagellum results from complex cellular events, including flagellum compartmentalization and membrane and organelle reorganization. These events are striking in the annulus, which progressively relocates from the neck to the principal piece of the flagellum. This study presents a human sperm phenotype with failure of the annulus relocation, absence of mitochondrial sheath and a fibrous sheath at intermediate step of assembly. The sperm nucleus was fully condensed but with deep invaginations engulfing the acrosome. The distal pole of some mitochondria exhibited an unusual dense substance. This rare human sperm phenotype was found in a consanguineous patient, suggesting a genetic origin. These anomalies raise the question of the mechanisms that lead to impairment of both the annulus relocation and the deposit of proteins on the fibrous sheath during spermiogenesis. |
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Authors:
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D Escalier |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Andrologia Volume: 38 ISSN: 0303-4569 ISO Abbreviation: Andrologia Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-13 Completed Date: 2006-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423506 Medline TA: Andrologia Country: Germany |
Other Details:
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Languages: eng Pagination: 54-60 Citation Subset: IM |
Affiliation:
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Andrology Department, University Paris XI, CHU Kremlin Bicêtre, France. denise.escalier@univ-paris5.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Male Microscopy Morphogenesis Sperm Midpiece / pathology Sperm Tail / pathology Spermatogenesis Spermatozoa / abnormalities*, growth & development, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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