Document Detail

Arrest of flagellum morphogenesis with fibrous sheath immaturity of human spermatozoa.
MedLine Citation:
PMID:  16529576     Owner:  NLM     Status:  MEDLINE    
Morphogenesis of the mammalian sperm flagellum is characterized by the assembly of axonemal and peri-axonemal structures. The incorporation of mitochondria into the flagellum results from complex cellular events, including flagellum compartmentalization and membrane and organelle reorganization. These events are striking in the annulus, which progressively relocates from the neck to the principal piece of the flagellum. This study presents a human sperm phenotype with failure of the annulus relocation, absence of mitochondrial sheath and a fibrous sheath at intermediate step of assembly. The sperm nucleus was fully condensed but with deep invaginations engulfing the acrosome. The distal pole of some mitochondria exhibited an unusual dense substance. This rare human sperm phenotype was found in a consanguineous patient, suggesting a genetic origin. These anomalies raise the question of the mechanisms that lead to impairment of both the annulus relocation and the deposit of proteins on the fibrous sheath during spermiogenesis.
D Escalier
Related Documents :
16700066 - The ovotestis: an underdeveloped organ of evolution.
1994976 - Nonisotopic in situ hybridization as a method for nondisjunction studies in human sperm...
17369546 - Fertilizing ability of chicken sperm bearing the w chromosome.
20430736 - Modification of equine sperm chromatin decondensation method to use fluorescence in sit...
11422006 - Frequencies of thiopurine s-methyltransferase mutant alleles (tpmt*2, *3a, *3b and *3c)...
522826 - Chromosome 1 abnormalities in relapse and terminal stages in childhood leukemia.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Andrologia     Volume:  38     ISSN:  0303-4569     ISO Abbreviation:  Andrologia     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-13     Completed Date:  2006-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  IM    
Andrology Department, University Paris XI, CHU Kremlin Bicêtre, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Sperm Midpiece / pathology
Sperm Tail / pathology
Spermatozoa / abnormalities*,  growth & development,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quality of life in elderly men with androgen deficiency.
Next Document:  Testosterone and erectile function in hypogonadal men unresponsive to tadalafil: results from an ope...