| Arrest of B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centers. | |
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MedLine Citation:
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PMID: 9655487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite extensive research, the role of CD40 signaling in B cell terminal differentiation remains controversial. Here we show that CD40 engagement arrests B cell differentiation prior to plasma cell formation. This arrest is manifested at a molecular level as a reduction in mRNA levels of secretory immunoglobulin gene products such as mu(s) and J chain as well as the loss of the transcriptional regulator BLIMP-1. Furthermore, the inhibition of B cell differentiation by CD40 engagement could not be overcome by either mitogens or cytokines, but could be reversed by antibodies that interfere with the CD40/gp39 interaction. These data suggest that secretory immunoglobulin is not produced by B cells that are actively engaged by gp39-expressing T cells. |
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Authors:
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T D Randall; A W Heath; L Santos-Argumedo; M C Howard; I L Weissman; F E Lund |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunity Volume: 8 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-23 Completed Date: 1998-07-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 733-42 Citation Subset: IM |
Affiliation:
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Trudeau Institute, Saranac Lake, New York 12983, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / immunology Antigens, CD40 / immunology* B-Lymphocytes / cytology, immunology* CD40 Ligand Cell Differentiation / immunology Coculture Techniques Germinal Center / cytology, immunology* Humans Ligands Membrane Glycoproteins / immunology Mice Mice, Inbred C57BL Repressor Proteins* Signal Transduction / immunology* Transcription Factors / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD40; 0/Ligands; 0/Membrane Glycoproteins; 0/Prdm1 protein, mouse; 0/Repressor Proteins; 0/Transcription Factors; 138415-26-6/PRDM1 protein, human; 147205-72-9/CD40 Ligand |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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