Document Detail


Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding.
MedLine Citation:
PMID:  18275435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A tiling path 33K BAC array was used to study 28 children with acute lymphoblastic leukaemia (ALL) who had normal or failed G-banded karyotypes. Twenty-two patients (79%) had a total of 135 copy number alterations (CNA) (69 gains and 66 losses); most of these patients showed CNA that were below the resolution of G-banding. Molecular cytogenetic and array comparative genomic hybridization results enabled the division of B-precursor ALL patients into five groups: high hyperdiploidy, intrachromosomal amplification of 21q, ETV6/RUNX1 rearrangement, others and no CNA. Apart from a shared deletion of 9p21.3, T-ALL patients had additional small CNA, with no region in common.
Authors:
Ekaterina Kuchinskaya; Mats Heyman; Ann Nordgren; Jacqueline Schoumans; Johan Staaf; Ake Borg; Stefan Söderhäll; Dan Grandér; Magnus Nordenskjöld; Elisabeth Blennow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  140     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-7     Citation Subset:  IM    
Affiliation:
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Ekaterina.Kuchinskaya@ki.se
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MeSH Terms
Descriptor/Qualifier:
Child
Chromosome Aberrations*
Chromosome Banding
Gene Dosage*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Nucleic Acid Hybridization
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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