Document Detail

Arousal and ventilatory responses to mild hypoxia in sleeping preterm infants.
MedLine Citation:
PMID:  18503514     Owner:  NLM     Status:  MEDLINE    
A failure to adequately respond to hypoxia has been implicated in the Sudden Infant Death Syndrome (SIDS). Preterm infants are at increased risk for SIDS, thus we compared ventilatory and arousal responses to mild hypoxia [15% oxygen (O2)] in preterm and term infants. Eight preterm and 15 term infants were serially studied with daytime polysomnography during which nasal airflow was monitored by pneumotachograph at 2-5 weeks, 2-3 and 5-6 months. At each age, in both groups, hypoxia induced a significant decrease in oxygen saturation (SpO2) during both active sleep (AS) and quiet sleep (QS). Infants invariably aroused in AS; and in QS either aroused or failed to arouse. In preterm infants arousal latency in AS was longer than in term infants (P < 0.05) at 2-5 weeks. Compared with term infants, preterm infants reached significantly lower SpO2 levels at 2-5 weeks in both AS and QS non-arousing tests and at 2-3 months in QS. A biphasic hypoxic ventilatory response was observed in QS non-arousing tests in both groups of infants at all three ages. We conclude that the greater desaturation during a hypoxic challenge combined with the longer arousal latency in preterm infants could contribute to greater risk for SIDS.
Marjan M A Verbeek; Heidi L Richardson; Peter M Parslow; Adrian M Walker; Richard Harding; Rosemary S C Horne
Related Documents :
2590114 - Child care practices and the sudden infant death syndrome.
20609624 - Cardiovascular control during sleep in infants: implications for sudden infant death sy...
582364 - Extramedullary hematopoiesis in the liver in sudden infant death syndrome.
8956944 - Infant behaviour in response to a change in body position from side to prone during sleep.
7324934 - Metabolic effects of obstetric regional analgesia and of asphyxia in the newborn infant...
7567484 - The development of attachment behaviors in pregnant adolescents.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-21
Journal Detail:
Title:  Journal of sleep research     Volume:  17     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  344-53     Citation Subset:  IM    
Ritchie Centre for Baby Health Research, Monash Institute for Medical Research, Melbourne, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / physiopathology*
Arousal / physiology*
Carbon Dioxide / blood
Gestational Age
Heart Rate / physiology
Infant, Newborn
Infant, Premature, Diseases / physiopathology*
Oxygen / blood
Pulmonary Ventilation / physiology*
Reaction Time / physiology
Reference Values
Risk Factors
Sleep Stages / physiology
Sudden Infant Death / blood
Tidal Volume / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Daytime sleepiness and neural cardiac modulation in sleep-related breathing disorders.
Next Document:  Guided tissue regeneration may modulate gene expression in periodontal intrabony defects: a human st...