Document Detail


Arousal and ventilatory responses to mild hypoxia in sleeping preterm infants.
MedLine Citation:
PMID:  18503514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A failure to adequately respond to hypoxia has been implicated in the Sudden Infant Death Syndrome (SIDS). Preterm infants are at increased risk for SIDS, thus we compared ventilatory and arousal responses to mild hypoxia [15% oxygen (O2)] in preterm and term infants. Eight preterm and 15 term infants were serially studied with daytime polysomnography during which nasal airflow was monitored by pneumotachograph at 2-5 weeks, 2-3 and 5-6 months. At each age, in both groups, hypoxia induced a significant decrease in oxygen saturation (SpO2) during both active sleep (AS) and quiet sleep (QS). Infants invariably aroused in AS; and in QS either aroused or failed to arouse. In preterm infants arousal latency in AS was longer than in term infants (P < 0.05) at 2-5 weeks. Compared with term infants, preterm infants reached significantly lower SpO2 levels at 2-5 weeks in both AS and QS non-arousing tests and at 2-3 months in QS. A biphasic hypoxic ventilatory response was observed in QS non-arousing tests in both groups of infants at all three ages. We conclude that the greater desaturation during a hypoxic challenge combined with the longer arousal latency in preterm infants could contribute to greater risk for SIDS.
Authors:
Marjan M A Verbeek; Heidi L Richardson; Peter M Parslow; Adrian M Walker; Richard Harding; Rosemary S C Horne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-21
Journal Detail:
Title:  Journal of sleep research     Volume:  17     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  344-53     Citation Subset:  IM    
Affiliation:
Ritchie Centre for Baby Health Research, Monash Institute for Medical Research, Melbourne, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Anoxia / physiopathology*
Arousal / physiology*
Carbon Dioxide / blood
Female
Gestational Age
Heart Rate / physiology
Humans
Infant, Newborn
Infant, Premature, Diseases / physiopathology*
Male
Oxygen / blood
Polysomnography
Pulmonary Ventilation / physiology*
Reaction Time / physiology
Reference Values
Risk Factors
Sleep Stages / physiology
Sudden Infant Death / blood
Tidal Volume / physiology
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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