Document Detail

Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking.
MedLine Citation:
PMID:  15109930     Owner:  NLM     Status:  MEDLINE    
Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At each age and in both groups, infants aroused more frequently and earlier to hypoxia in active sleep (AS) than quiet sleep (QS). Arousal latency was longer in SM infants (in QS) at 5-6 months (P < 0.05). Baseline respiratory parameters were not different between groups, except that, at 2-3 months, SM infants had higher SP(O2) during AS than NS infants. Maternal smoking did not affect ventilatory responses preceding hypoxia-induced arousal in either sleep-state at any age. We conclude that mild hypoxia stimulates ventilation and arousal in infants up to 6 months and that arousability is depressed in SM infants at 5-6 months; however, ventilatory responses preceding arousal are not adversely affected by smoking.
Peter M Parsiow; Peter M Parslow; Susan M Cranage; T Michael Adamson; Richard Harding; Rosemary S C Horne
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  140     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-87     Citation Subset:  IM    
Department of Paediatrics, Ritchie Centre for Baby Health Research, Monash University, Level 5, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia.
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MeSH Terms
Anoxia / physiopathology*
Arousal / physiology*
Infant, Newborn
Longitudinal Studies
Matched-Pair Analysis
Maternal Exposure
Pregnancy Complications
Prenatal Exposure Delayed Effects*
Pulmonary Ventilation / physiology
Reaction Time / physiology
Respiratory Mechanics / physiology*
Sleep / physiology*
Sleep Stages / physiology
Smoking / adverse effects*
Erratum In:
Respir Physiol Neurobiol. 2004 Oct 12;143(1):99
Note: Parsiow, PM [corrected to Parslow, PM]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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