| Arousal and ventilatory responses to hypoxia in sleeping infants: effects of maternal smoking. | |
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MedLine Citation:
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PMID: 15109930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At each age and in both groups, infants aroused more frequently and earlier to hypoxia in active sleep (AS) than quiet sleep (QS). Arousal latency was longer in SM infants (in QS) at 5-6 months (P < 0.05). Baseline respiratory parameters were not different between groups, except that, at 2-3 months, SM infants had higher SP(O2) during AS than NS infants. Maternal smoking did not affect ventilatory responses preceding hypoxia-induced arousal in either sleep-state at any age. We conclude that mild hypoxia stimulates ventilation and arousal in infants up to 6 months and that arousability is depressed in SM infants at 5-6 months; however, ventilatory responses preceding arousal are not adversely affected by smoking. |
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Authors:
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Peter M Parsiow; Peter M Parslow; Susan M Cranage; T Michael Adamson; Richard Harding; Rosemary S C Horne |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 140 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-27 Completed Date: 2004-07-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 77-87 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Ritchie Centre for Baby Health Research, Monash University, Level 5, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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physiopathology* Arousal / physiology* Female Humans Infant, Newborn Longitudinal Studies Male Matched-Pair Analysis Maternal Exposure Polysomnography Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects* Pulmonary Ventilation / physiology Reaction Time / physiology Respiration Respiratory Mechanics / physiology* Sleep / physiology* Sleep Stages / physiology Smoking / adverse effects* |
| Comments/Corrections | |
Erratum In:
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Respir Physiol Neurobiol. 2004 Oct 12;143(1):99 Note: Parsiow, PM [corrected to Parslow, PM] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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