Document Detail


Arousal and differential Fos expression in histaminergic neurons of the ascending arousal system during a feeding-related motivated behaviour.
MedLine Citation:
PMID:  15869486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arousal depends on the concerted activity of the ascending arousal system (AAS) but specific stimuli may primarily activate some nuclei of this system. Motivated behaviours are characterized by behavioural arousal, although it is not known which AAS nuclei are active during a motivated behaviour. To address this issue, rats were rendered motivated for food by fasting them for 1 day and then were enticed with food that they could not obtain for varying periods of time. We studied the level of arousal by polysomnography or radiotelemetry, and Fos-ir in the AAS, during food enticing. We found a strong arousal and an early increase in Fos-ir in the histaminergic neurons from the tuberomammillary nucleus, after 30 min of enticing, followed by increased Fos-ir in the whole AAS if food enticing was prolonged to 1 or 2 hours. In contrast, food presentation to non-motivated rats did not increase arousal or Fos-ir in the tuberomammillary nucleus. As opposed to the active arousal of the motivated rats, passive arousal induced by sensory stimulation was associated with increased Fos-ir in the locus coeruleus and the orexin neurons, but not with increased Fos-ir in the tuberomammillary nucleus or in the other nuclei of the AAS. We conclude that the arousal during feeding-related motivated behaviour is associated primarily with the activation of the tuberomammillary nucleus, while the other arousal-related nuclei become active later on.
Authors:
J L Valdés; P Farías; A Ocampo-Garcés; N Cortés; M Serón-Ferré; F Torrealba
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  21     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-04     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1931-42     Citation Subset:  IM    
Affiliation:
Programa de Doctorado en Ciencias Biomédicas, ICBM, Universidad de Chile, Santiago, Chile.
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MeSH Terms
Descriptor/Qualifier:
Afferent Pathways / cytology,  metabolism
Animals
Arousal / physiology*
Behavior, Animal
Body Temperature / physiology
Cell Count / methods
Feeding Behavior / physiology*
Food
Gene Expression Regulation / physiology*
Histamine / metabolism*
Hypothalamus / cytology,  metabolism
Immunohistochemistry / methods
Male
Motivation*
Motor Activity / physiology
Neurons / metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Rats, Sprague-Dawley
Time Factors
Tyrosine 3-Monooxygenase / metabolism
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 51-45-6/Histamine; EC 1.14.16.2/Tyrosine 3-Monooxygenase

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