Document Detail


Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen.
MedLine Citation:
PMID:  7567987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Different autoantigens are thought to be involved in the pathogenesis of insulin-dependent diabetes mellitus, and they may account for the variation in the clinical presentation of the disease. Sera from patients with autoimmune polyendocrine syndrome type I contain autoantibodies against the beta-cell proteins glutamate decarboxylase and an unrelated 51-kDa antigen. By screening of an expression library derived from rat insulinoma cells, we have identified the 51-kDa protein as aromatic-L-amino-acid decarboxylase (EC 4.1.1.28). In addition to the previously published full-length cDNA, forms coding for a truncated and an alternatively spliced version were identified. Aromatic L-amino acid decarboxylase catalyzes the decarboxylation of L-5-hydroxytryptophan to serotonin and that of L-3,4-dihydroxyphenylalanine to dopamine. Interestingly, pyridoxal phosphate is the cofactor of both aromatic L-amino acid decarboxylase and glutamate decarboxylase. The biological significance of the neurotransmitters produced by the two enzymes in the beta cells remains largely unknown.
Authors:
F Rorsman; E S Husebye; O Winqvist; E Björk; F A Karlsson; O Kämpe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  92     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-23     Completed Date:  1995-10-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8626-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital, Uppsala University, Sweden.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U31884
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Glands / immunology
Amino Acid Sequence
Animals
Aromatic-L-Amino-Acid Decarboxylases / genetics,  immunology*
Autoantigens / genetics,  immunology*
Base Sequence
Diabetes Mellitus, Type 1 / immunology
Female
Gene Library
Gonads / immunology
Humans
Islets of Langerhans / immunology*
Molecular Sequence Data
Parathyroid Glands / immunology
Polyendocrinopathies, Autoimmune / classification,  immunology*
Precipitin Tests
Rats
Rats, Inbred WF
Recombinant Proteins / immunology
Selection, Genetic
Sequence Analysis, DNA
Syndrome
Chemical
Reg. No./Substance:
0/Autoantigens; 0/Recombinant Proteins; EC 4.1.1.28/Aromatic-L-Amino-Acid Decarboxylases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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