| Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. | |
| | |
MedLine Citation:
|
PMID: 7567987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Different autoantigens are thought to be involved in the pathogenesis of insulin-dependent diabetes mellitus, and they may account for the variation in the clinical presentation of the disease. Sera from patients with autoimmune polyendocrine syndrome type I contain autoantibodies against the beta-cell proteins glutamate decarboxylase and an unrelated 51-kDa antigen. By screening of an expression library derived from rat insulinoma cells, we have identified the 51-kDa protein as aromatic-L-amino-acid decarboxylase (EC 4.1.1.28). In addition to the previously published full-length cDNA, forms coding for a truncated and an alternatively spliced version were identified. Aromatic L-amino acid decarboxylase catalyzes the decarboxylation of L-5-hydroxytryptophan to serotonin and that of L-3,4-dihydroxyphenylalanine to dopamine. Interestingly, pyridoxal phosphate is the cofactor of both aromatic L-amino acid decarboxylase and glutamate decarboxylase. The biological significance of the neurotransmitters produced by the two enzymes in the beta cells remains largely unknown. |
| | |
Authors:
|
F Rorsman; E S Husebye; O Winqvist; E Björk; F A Karlsson; O Kämpe |
Related Documents
:
|
8457887 - Altered metabolism of excitatory amino acids, n-acetyl-aspartate and n-acetyl-aspartyl-... 15495357 - A comparison of in vitro fertilization outcome by culture media used for developing cle... 11519717 - Synthesis and characterization of n,n-dichlorinated amino acids: taurine, homotaurine, ... 12376667 - Coupling sap flow velocity and amino acid concentrations as an alternative method to (1... 8902277 - S-methylation of o,o-dialkyl phosphorodithioic acids: o,o,s-trimethyl phosphorodithioat... 16981437 - Single-step analysis of individual conjugated bile acids in human bile using 1h nmr spe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1995 Sep |
Date Detail:
|
Created Date: 1995-10-23 Completed Date: 1995-10-23 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 8626-9 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University Hospital, Uppsala University, Sweden. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/U31884 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenal Glands / immunology Amino Acid Sequence Animals Aromatic-L-Amino-Acid Decarboxylases / genetics, immunology* Autoantigens / genetics, immunology* Base Sequence Diabetes Mellitus, Type 1 / immunology Female Gene Library Gonads / immunology Humans Islets of Langerhans / immunology* Molecular Sequence Data Parathyroid Glands / immunology Polyendocrinopathies, Autoimmune / classification, immunology* Precipitin Tests Rats Rats, Inbred WF Recombinant Proteins / immunology Selection, Genetic Sequence Analysis, DNA Syndrome |
| Chemical | |
Reg. No./Substance:
|
0/Autoantigens; 0/Recombinant Proteins; EC 4.1.1.28/Aromatic-L-Amino-Acid Decarboxylases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of cDNA clones encoding RICH: a protein induced during goldfish optic nerve regeneration w...
Next Document: Postseptational chromosome partitioning in bacteria.