| Aromatic L-amino acid decarboxylase activities in human lung tissues: comparison between normal lung and lung carcinomas. | |
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MedLine Citation:
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PMID: 2996509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured the activity of aromatic L-amino acid decarboxylase with L-dihydroxyphenylalanine as a substrate (DOPA decarboxylase) in normal lung tissues and lung tumors obtained fresh at surgery. The activity in control human lung tissues was low and variable: 3.50 +/- 0.42 pmole/min/mg protein (n = 56, mean +/- SE, range 0.01-15), indicating the wide individual variations. Most of small cell carcinoma specimens showed very high activity, as compared with both control lung tissues and with other types of non-SCC lung cancers. Similar results were also obtained in the athymic mice heterotransplants of SCC. High activity was also observed using 5-L-hydroxytryptophan as a substrate (5-HTP decarboxylase) in nine SCC samples. Serotonin was not detected in any control lung tissues, but was detected in all the nine SCC samples, but dopamine was detected only in three out of nine SCC samples. |
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Authors:
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T Nagatsu; H Ichinose; K Kojima; T Kameya; J Shimase; T Kodama; Y Shimosato |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical medicine Volume: 34 ISSN: 0006-2944 ISO Abbreviation: Biochem Med Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-11-04 Completed Date: 1985-11-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151424 Medline TA: Biochem Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 52-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aromatic-L-Amino-Acid Decarboxylases / metabolism* Carcinoma, Small Cell / enzymology Dopa Decarboxylase / metabolism Humans Lung / enzymology* Lung Neoplasms / enzymology* Mice Mice, Nude Neoplasm Transplantation Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
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EC 4.1.1.-/Dopa Decarboxylase; EC 4.1.1.28/Aromatic-L-Amino-Acid Decarboxylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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