Document Detail


Aromatase inhibitor treatment of menorrhagia and subsequent pregnancy in a patient with familial hyperparathyroidism-jaw tumor syndrome.
MedLine Citation:
PMID:  22963808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the clinical management of menorrhagia in a woman with hyperparathyroidism-jaw tumor syndrome (HPT-JT).
DESIGN: Case report.
SETTING: Large translation research hospital.
PATIENT(S): A 26-year-old nulligravid woman with familial HPT-JT presented with life-long menorrhagia resistant to progesterone intrauterine device (IUD) therapy and a desire for fertility.
INTERVENTION(S): Aromatase inhibitor therapy.
MAIN OUTCOME MEASURE(S): Clinical response to therapy and pregnancy.
RESULT(S): Imaging demonstrated an enlarged endometrial lining and thickening of the junctional zone. At operative hysteroscopy, multiple atypical endometrial polyp-like lesions filled the entire uterine cavity and were removed. Histologic evaluation demonstrated the lesions to be adenomyomas with an abundance of aromatase expression. Postoperative treatment included an aromatase inhibitor. The patient's menorrhagia, which had previously been resistant to progesterone IUD therapy, resolved with the aromatase inhibitor. After 10 months of this treatment, the aromatase inhibitor was discontinued and a repeated hysteroscopy revealed a markedly improved uterine cavity. The patient subsequently became pregnant on her first natural cycle and delivered a healthy term infant.
CONCLUSION(S): Aromatase inhibitors may represent a novel treatment for benign uterine pathology in HPT-JT.
Authors:
Erin F Wolff; Micah J Hill; William F Simonds; James H Segars
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-09-08
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-05     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1616-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / drug therapy*
Aromatase Inhibitors / therapeutic use*
Female
Fibroma / drug therapy*
Humans
Hyperparathyroidism / drug therapy*
Infertility, Female / drug therapy*
Jaw Neoplasms / drug therapy*
Live Birth
Menorrhagia / drug therapy*
Ovulation Induction / methods*
Pregnancy
Treatment Outcome
Grant Support
ID/Acronym/Agency:
Z01 HD008924-01/HD/NICHD NIH HHS; Z01 ND008737-12/ND/ONDIEH CDC HHS; Z99 HD999999/HD/NICHD NIH HHS; ZIA HD008924-01/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Aromatase Inhibitors
Comments/Corrections

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