Document Detail


Aromatase inhibitor-induced skin adverse reactions: exemestane-related cutaneous vasculitis.
MedLine Citation:
PMID:  21492245     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background  Three aromatase inhibitors, namely anastrozole, letrozole and exemestane, which reduce circulating oestrogen, are used to treat breast cancer patients; the therapeutic use of such aromatase inhibitors is quickly increasing. Objective  We intended (i) to review aromatase inhibitor-induced cutaneous adverse effects and (ii) to describe a recently observed case of cutaneous vasculitis triggered by exemestane. Patients/methods  The so-far reported literature cases of aromatase inhibitor-induced cutaneous adverse effects were analysed retrospectively. Especially, the clinical case of exemestane-induced cutaneous vasculitis herein reported is unique, because such an observation has not yet been published in the literature. Results  Merely 12 cases of cutaneous adverse reactions induced by aromatase inhibitors, namely erythema nodosum (6), subacute cutaneous lupus erythematosus (1), cutaneous rashes (2), vasculitis (3, including the one described in this study), are reported in the literature. In fact, in the present case, cutaneous vasculitis was strictly related to exemestane. Conclusion  As aromatase inhibitors (e.g. exemestane) are increasingly incorporated into the treatment strategy of breast cancer patients, it is important to recognize possible cutaneous adverse effects. Specifically, with regard to cutaneous vasculitis, some patients might progress to severe vasculitis manifestations if the offending drug (e.g. exemestane) is not quickly stopped.
Authors:
S Santoro; M Santini; Ca Pepe; E Tognetti; C Cortelazzi; E Ficarelli; G De Panfilis
Related Documents :
7713135 - Subcutaneous metastases after coelioscopic lymphadenectomy for vesical urothelial carci...
9730765 - Neoplasia-like echographic evidence in retinopathies of several aetiologies: a case rep...
9279565 - Expression and prognostic value of c-erbb-2 oncogene product in human phaeochromocytomas.
12571385 - A unique presentation of retroclival chordoma.
3775605 - Premature closure of the ductus arteriosus causing intra-uterine death. a case report.
11013695 - Pineal apoplexy: an occurrence with no diagnostic clinicopathological features.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  25     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  596-8     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
Affiliation:
Section of Dermatology, Department of Surgical Sciences, Parma University, Parma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optimizing the treatment of atopic dermatitis in children: a review of the benefit/risk ratio of met...
Next Document:  Treatment of pigmented purpuric dermatoses with Narrow-band UVB: a report of six cases.