| Aromatase inhibitor-induced skin adverse reactions: exemestane-related cutaneous vasculitis. | |
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MedLine Citation:
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PMID: 21492245 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Three aromatase inhibitors, namely anastrozole, letrozole and exemestane, which reduce circulating oestrogen, are used to treat breast cancer patients; the therapeutic use of such aromatase inhibitors is quickly increasing. Objective We intended (i) to review aromatase inhibitor-induced cutaneous adverse effects and (ii) to describe a recently observed case of cutaneous vasculitis triggered by exemestane. Patients/methods The so-far reported literature cases of aromatase inhibitor-induced cutaneous adverse effects were analysed retrospectively. Especially, the clinical case of exemestane-induced cutaneous vasculitis herein reported is unique, because such an observation has not yet been published in the literature. Results Merely 12 cases of cutaneous adverse reactions induced by aromatase inhibitors, namely erythema nodosum (6), subacute cutaneous lupus erythematosus (1), cutaneous rashes (2), vasculitis (3, including the one described in this study), are reported in the literature. In fact, in the present case, cutaneous vasculitis was strictly related to exemestane. Conclusion As aromatase inhibitors (e.g. exemestane) are increasingly incorporated into the treatment strategy of breast cancer patients, it is important to recognize possible cutaneous adverse effects. Specifically, with regard to cutaneous vasculitis, some patients might progress to severe vasculitis manifestations if the offending drug (e.g. exemestane) is not quickly stopped. |
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Authors:
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S Santoro; M Santini; Ca Pepe; E Tognetti; C Cortelazzi; E Ficarelli; G De Panfilis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: 25 ISSN: 1468-3083 ISO Abbreviation: J Eur Acad Dermatol Venereol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 596-8 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology. |
Affiliation:
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Section of Dermatology, Department of Surgical Sciences, Parma University, Parma, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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