| Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility. | |
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MedLine Citation:
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PMID: 12871867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adding clomiphene citrate (CC) to FSH for controlled ovarian stimulation (COS) decreases FSH dose required for optimum stimulation. However, because of its anti-estrogenic effects, CC may be associated with lower pregnancy rates offsetting the FSH-dose reduction benefit. Previously, we reported the success of aromatase inhibition in inducing ovulation without antiestrogenic effects. METHODS: A prospective pilot study that included women with unexplained infertility undergoing COS and intrauterine insemination. Thirty-six women received the aromatase inhibitor letrozole + FSH, 18 women received CC + FSH and 56 women received FSH only. Each woman received one treatment regimen in one treatment cycle. All patients were given recombinant or highly purified FSH (50-150 IU/day) starting on day 3 to 7 until day of hCG. RESULTS: The FSH dose needed was significantly lower in letrozole + FSH and CC + FSH groups compared with FSH-only without a difference in number of follicles >1.8 cm. Pregnancy rate was 19.1% in the letrozole + FSH group, 10.5% in the CC + FSH group and 18.7% in the FSH-only group. Both pregnancy rate and endometrial thickness were significantly lower in CC + FSH group compared with the other two groups. Estradiol (E2) levels were significantly lower in the letrozole + FSH group compared with the other two groups. CONCLUSIONS: Similar to CC, aromatase inhibition with letrozole reduces FSH dose required for COS without the undesirable antiestrogenic effects sometimes seen with CC. |
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Authors:
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M F M Mitwally; R F Casper |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 18 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-21 Completed Date: 2004-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1588-97 Citation Subset: IM |
Affiliation:
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Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics & Gynecology, University of Toronto, Toronto, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aromatase Inhibitors* Clomiphene / administration & dosage Enzyme Inhibitors / administration & dosage Estradiol / blood Female Fertility Agents, Female / administration & dosage Follicle Stimulating Hormone, Human / administration & dosage* Humans Infertility, Female / blood, drug therapy*, ultrasonography Luteinizing Hormone / blood Nitriles / administration & dosage Ovarian Follicle / drug effects, ultrasonography Ovulation Induction / methods* Pilot Projects Pregnancy Prospective Studies Triazoles / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Aromatase Inhibitors; 0/Enzyme Inhibitors; 0/Fertility Agents, Female; 0/Follicle Stimulating Hormone, Human; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone; 911-45-5/Clomiphene |
| Comments/Corrections | |
Comment In:
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Hum Reprod. 2003 Aug;18(8):1598-602
[PMID:
12871868
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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