Document Detail


Armand M. Karow, Jr.: Looking back.
MedLine Citation:
PMID:  19766616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Armand Karow, Jr. was a devoted scholar of cryobiology who was responsible for the creation of landmark books and many unique observations. Driven into cryobiology by a fascination with organ cryopreservation that dated from his high school days, Karow carried out or contributed to research on the cryopreservation of hearts, kidneys, pancreatic islets, and reproductive cells and tissues. His interests included not only conventional issues in cryobiology such as cryoprotectant permeation kinetics, theories of freezing injury in cells and tissues, and electromagnetic warming of large organs, but also more esoteric questions such as the limits of tolerance of mammalian organs to high pressures, the role of molecular hydration in cell viability, the pharmacological effects of cryoprotectants (which he frequently referred to as drugs), the limits of cryoprotectant tolerance at higher temperatures, and low temperature pharmacology. A look back at some of the discoveries made by Karow and his colleagues reveals many interesting leads whose further investigation could continue to provide valuable new insights in the future.
Authors:
Gregory M Fahy
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Cryobiology     Volume:  60     ISSN:  1090-2392     ISO Abbreviation:  Cryobiology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006252     Medline TA:  Cryobiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S2-12     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Affiliation:
21st Century Medicine, Inc., 14960 Hilton Drive, Fontana, CA 92336, USA. gfahy@21cm.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Biology / history*
Cryopreservation / history*
Cryoprotective Agents / history
Electromagnetic Phenomena
Freezing
History, 20th Century
History, 21st Century
Humans
Organ Preservation / history*
United States
Chemical
Reg. No./Substance:
0/Cryoprotective Agents
Personal Name Subject
Personal Name Subject:
Armand M Karow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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