Document Detail


Armadillo repeat-containing kinesins and a NIMA-related kinase are required for epidermal-cell morphogenesis in Arabidopsis.
MedLine Citation:
PMID:  17971038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The involvement of kinesin motor proteins in both cell-tip growth and cell-shape determination has been well characterized in various organisms. However, the functions of kinesins during cell morphogenesis in higher plants remain largely unknown. In the current study, we demonstrate that an armadillo repeat-containing kinesin-related protein, ARMADILLO REPEAT KINESIN1 (ARK1), is involved in root-hair morphogenesis. Microtubule polymers are more abundant in ark1 null allele root hairs, but analysis shows that these extra microtubules are concentrated in the endoplasm, and not in the cortical array, suggesting that ARK1 regulates tip growth by limiting the assembly and distribution of endoplasmic microtubules. The ARK1 gene has two homologues in the Arabidopsis genome, ARK2 and ARK3, and our results show that ARK2 is involved in root-cell morphogenesis. We further reveal that a NIMA-related protein kinase, NEK6, binds to the ARK family proteins and has pleiotropic effects on epidermal-cell morphogenesis, suggesting that NEK6 is involved in cell morphogenesis in Arabidopsis via microtubule functions associated with these armadillo repeat-containing kinesins. We discuss the function of NIMA-related protein kinases and armadillo repeat-containing kinesins in the cell morphogenesis of eukaryotes.
Authors:
Tatsuya Sakai; Hannie van der Honing; Miki Nishioka; Yukiko Uehara; Mihoko Takahashi; Noriko Fujisawa; Kensuke Saji; Motoaki Seki; Kazuo Shinozaki; Mark A Jones; Nicholas Smirnoff; Kiyotaka Okada; Geoffrey O Wasteneys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-30
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  53     ISSN:  0960-7412     ISO Abbreviation:  Plant J.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-71     Citation Subset:  IM    
Affiliation:
RIKEN Plant Science Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics,  physiology*
Armadillo Domain Proteins / chemistry*
Cell Cycle Proteins / physiology*
Cell Differentiation
Genes, Plant
Kinesin / biosynthesis,  chemistry,  genetics,  physiology*
Microtubules / metabolism
Morphogenesis / physiology*
Plant Roots / growth & development
Protein-Serine-Threonine Kinases / physiology*
Chemical
Reg. No./Substance:
0/Armadillo Domain Proteins; 0/Cell Cycle Proteins; EC 2.7.1.-/NIMA protein kinase; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.6.1.-/Kinesin

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