| Arm blood flow and metabolism during arm and combined arm and leg exercise in humans. | |
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MedLine Citation:
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PMID: 12411540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiovascular response to exercise with several groups of skeletal muscle suggests that work with the arms may decrease leg blood flow. This study evaluated whether intense exercise with the legs would have a similar effect on arm blood flow (Y(arm)) and O(2) consumption (V(O(2))(,arm)). Ten healthy male subjects (age 21 +/- 1 year; mean +/- S.D.) performed arm cranking at 80 % of maximum arm work capacity (A trial) and combined arm cranking with cycling at 60 % of maximum leg work capacity (A + L trial). The combined trial was a maximum effort for 5-6 min. Y(arm) measurement by thermodilution in the axilliary vein and arterial and venous blood samples permitted calculation of V(O(2))(,arm). During the combined trial, Y(arm) was reduced by 0.58 +/- 0.25 l min(-1) (19.1 +/- 3.0 %, P < 0.05) from the value during arm cranking (3.00 +/- 0.46 l min(-1)). The arterio-venous O(2) difference increased from 122 +/- 15 ml l(-1) during the arm trial to 150 +/- 21 ml l(-1) (P < 0.05) during the combined trial. Thus, V(O(2))(,arm) (0.45 +/- 0.06 l min(-1)) was reduced by 9.6 +/- 6.3 % (P < 0.05) and arm vascular conductance from 27 +/- 4 to 23 +/- 3 ml min(-1) (mmHg)(-1) (P < 0.05) as noradrenaline spillover from the arm increased from 7.5 +/- 3.5 to 13.8 +/- 4.2 nmol min(-1) (P < 0.05). The data suggest that during maximal whole body exercise in humans, arm vasoconstriction is established to an extent that affects oxygen delivery to and utilisation by working skeletal muscles. |
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Authors:
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S Volianitis; N H Secher |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 544 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-04 Completed Date: 2003-05-01 Revised Date: 2013-06-09 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 977-84 Citation Subset: IM |
Affiliation:
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Copenhagen Muscle Research Centre, Department of Anaesthesia, Rigshospitalet, Denmark. Stefanos.Volianitis@excite.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arm* Arteries Calcium / blood Exercise / physiology* Humans Hydrogen-Ion Concentration Lactic Acid / blood Leg* Male Muscle, Skeletal / blood supply*, physiology* Oxygen / blood Oxygen Consumption Regional Blood Flow Veins |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 7440-70-2/Calcium; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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