Document Detail

Aristolochic acid nephropathy in a Chinese patient: time to abandon the term "Chinese herbs nephropathy"?
MedLine Citation:
PMID:  11684578     Owner:  NLM     Status:  MEDLINE    
The causal role of aristolochic acid (AA) in the so-called Chinese herbs nephropathy (CHN) has been conclusively demonstrated only in the Belgian epidemic. We report a biopsy-proven hypocellular interstitial fibrosing nephropathy in a Chinese patient who had ingested a Chinese herbal preparation bought in Shanghai. The identification of AA in the preparation and of AA-DNA adducts in the kidney tissue unequivocally demonstrates, for the first time, the causal role of AA outside the Belgian epidemic. Because the ingested preparation is very popular in China as an over-the-counter product, our observation raises the possibility that many such cases due to AA might be currently unrecognized in China. AA should be banned from herbal preparations worldwide. All cases of the so-called CHN, in which the causal role of AA has been thoroughly documented, should be further identified as aristolochic acid nephropathy (AAN). The term phytotherapy-associated interstitial nephritis (PAIN) might refer to the other cases associated with phytotherapy without identification, as yet, of the causal agent.
G Gillerot; M Jadoul; V M Arlt; C van Ypersele De Strihou; H H Schmeiser; P P But; C A Bieler; J P Cosyns
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  38     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E26     Citation Subset:  IM    
Departments of Nephrology and Pathology, Cliniques St. Luc, Université catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Aristolochic Acids*
DNA Adducts
Drugs, Chinese Herbal / adverse effects
Kidney / drug effects,  pathology,  physiopathology
Kidney Failure / chemically induced*
Middle Aged
Phenanthrenes / adverse effects*
Terminology as Topic
Reg. No./Substance:
0/Aristolochic Acids; 0/DNA Adducts; 0/Drugs, Chinese Herbal; 0/Phenanthrenes; 313-67-7/aristolochic acid I
Comment In:
Am J Kidney Dis. 2001 Nov;38(5):1141-2   [PMID:  11684575 ]

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