Document Detail

Argyrophilic nucleolar organizer regions (AgNORs) in mucosal epithelium under experimental denture bases in rats.
MedLine Citation:
PMID:  10678714     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate changes in the argyrophilic nucleolar organizer region (AgNOR) counts in mucosal epithelium induced by continuous or intermittent compressive pressure exerted through experimental denture bases and to examine the relationships between the AgNOR count, histopathological changes and the intensity of the pressure under denture bases. Continuous or intermittent compressive pressure exerted through the denture bases was applied to the hard palate of the molar region in rats. A morphometric analysis of AgNORs was performed in denture-supporting tissue 3 days and 1, 2, 4, 8, 12 and 20 weeks after the denture insertion. From the results of this study, it was found that non-pressure contact of the denture bases with palatal tissues did not change the AgNOR count. The AgNOR count was decreased by continuous or intermittent compressive pressure, and then recovered to almost the same level as with the non-pressure contact at 20 weeks following a decrease of the pressure. The AgNOR counts in the epithelium under the denture bases were revealed to be related to the histopathological changes in the denture-supporting tissues and the intensity of the pressure under the denture bases.
T Hara; T Sato; S Mori; H Shirai; Y Maruo; S Minagi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  29     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-01     Completed Date:  2000-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  D; IM    
Department of Removable Prosthodontics, Okayama University Dental School, Japan.
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MeSH Terms
Acrylic Resins / adverse effects*
Denture Bases / adverse effects*
Denture, Partial, Removable / adverse effects
Epithelial Cells / ultrastructure
Mouth Mucosa / ultrastructure*
Nucleolus Organizer Region / pathology*
Pressure / adverse effects
Rats, Wistar
Silver Staining
Statistics, Nonparametric
Time Factors
Reg. No./Substance:
0/Acrylic Resins
Comment In:
J Oral Pathol Med. 2000 Nov;29(10):526-7   [PMID:  11048971 ]

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