Document Detail


Argyrophilic nucleolar organizer region counts in exfoliative cytology of buccal mucosa from opium addicts, smokers and nonsmokers.
MedLine Citation:
PMID:  18980159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the argyrophilic nucleolar organizer region (AgNOR) count of cells collected from the normal buccal mucosa of cigarette smokers, opium addicts and nonsmokers.
STUDY DESIGN: Exfoliative cytologic smears of buccal mucosa from 25 smokers, 25 addicts and 25 nonsmokers were stained for AgNORs according to the Ploton's method. The AgNOR count was performed on 100 cells. These AgNOR counts were compared and analyzed using the SPSS 13 program (SPSS, Inc., Chicago, Illinois, U.S.A.) and one-way ANOVA test.
RESULTS: Statistically, the highest mean AgNOR count (mAgNOR) was in cells from opium addicts (9.21 +/- 2.95) and the lowest in cells from nonsmokers (4.35 +/- 1.62) (p < 0.0001). For smokers, this value was in midrange (5.68 +/- 2.17). The percentage of cells with 6 or more AgNORs (pAgNOR > or =6) was the best discriminator among the different groups (p < 0.0001).
CONCLUSION: Cigarette smoking and particularly opium abuse increases the rate of cellular proliferation in cells of normal buccal mucosa.
Authors:
Maryam Kadivar; Mehrnoush Attar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology     Volume:  30     ISSN:  0884-6812     ISO Abbreviation:  Anal. Quant. Cytol. Histol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-11-26     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  8506819     Medline TA:  Anal Quant Cytol Histol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinoma, Squamous Cell / pathology
Cell Division
Female
Humans
Male
Mouth Mucosa / pathology*
Mouth Neoplasms / pathology
Nucleolus Organizer Region / pathology*
Opioid-Related Disorders / pathology*
Silver Staining
Smoking / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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