| Argyrophilic grain disease: synergistic component of dementia? | |
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MedLine Citation:
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PMID: 19963233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Argyrophilic grain disease (AGD) is one cause of neurodegenerative dementia with a variable clinical spectrum. A neuropathology study is required for diagnosis. CASE REPORT: We report the case of a 68-year-old patient presenting with cognitive decline associating with frontal dysfunction and parkinsonism. Death occurred two years after onset. The neuropathology study revealed a status criblosus in the basal ganglia, neurofibrillary tangles and AGD. DISCUSSION: We suggest that AGD could explain the atypical course of this dementia considering the fast cognitive decline, the clinical expression and the topography of the lesions. CONCLUSION: This case illustrates the possible synergistic deleterious effect of this pathology on other causes of dementia. |
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Authors:
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D Wallon; C Sommervogel; A Laquerri?re; O Martinaud; M Lecourtois; D Hannequin |
Publication Detail:
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Type: Case Reports; English Abstract; Journal Article Date: 2009-12-05 |
Journal Detail:
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Title: Revue neurologique Volume: 166 ISSN: 0035-3787 ISO Abbreviation: Rev. Neurol. (Paris) Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984779R Medline TA: Rev Neurol (Paris) Country: France |
Other Details:
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Languages: fre Pagination: 428-32 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Service de Neurologie, Universit? de Rouen, CHU Charles-Nicolle, 1 Rue de Germont, 76031 Rouen Cedex, France. david.wallon@gmail.com |
Vernacular Title:
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Maladie des grains argyrophiles: composante synergique de la d?mence ? |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Basal Ganglia / pathology Basal Ganglia Diseases / pathology Cerebral Cortex / pathology Cognition / physiology Dementia / pathology, psychology* Fatal Outcome Humans Male Neurodegenerative Diseases / pathology, psychology* Neurofibrillary Tangles / pathology Parkinson Disease / complications, psychology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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