Document Detail

Argon pneumoperitoneum is more dangerous than CO2 pneumoperitoneum during venous gas embolism.
MedLine Citation:
PMID:  9390610     Owner:  NLM     Status:  MEDLINE    
We investigated the possibility of using argon, an inert gas, as a replacement for carbon dioxide (CO2). The tolerance of argon pneumoperitoneum was compared with that of CO2 pneumoperitoneum. Twenty pigs were anesthetized with enflurane 1.5%. Argon (n = 11) or CO2 (n = 9) pneumoperitoneum was created at 15 mm Hg over 20 min, and serial intravenous injections of each gas (ranging from 0.1 to 20 mL/kg) were made. Cardiorespiratory variables were measured. Transesophageal Doppler and capnographic monitoring were assessed in the detection of embolism. During argon pneumoperitoneum, there was no significant change from baseline in arterial pressure and pulmonary excretion of CO2, mean systemic arterial pressure (MAP), mean pulmonary artery pressure (PAP), or systemic and pulmonary vascular resistances, whereas CO2 pneumoperitoneum significantly increased these values (P < 0.05). During the embolic trial and from gas volumes of 2 and 0.2 mL/kg, the decrease in MAP and the increase in PAP were significantly higher with argon than with CO2 (P < 0.05). In contrast to CO2, argon pneumoperitoneum was not associated with significant changes in cardiorespiratory functions. However, argon embolism seems to be more deleterious than CO2 embolism. The possibility of using argon pneumoperitoneum during laparoscopy remains uncertain. Implications: Laparoscopic surgery requires insufflation of gas into the peritoneal cavity. We compared the hemodynamic effects of argon, an inert gas, and carbon dioxide in a pig model of laparoscopic surgery. We conclude that argon carries a high risk factor in the case of an accidental gas embolism.
C Mann; G Boccara; V Grevy; F Navarro; J M Fabre; P Colson
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  85     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1997-12-19     Completed Date:  1997-12-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1367-71     Citation Subset:  AIM; IM; S    
Department of Anesthesia, Hopital Saint-Eloi, Montpellier, France.
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MeSH Terms
Carbon Dioxide*
Embolism, Air / diagnosis,  etiology*,  physiopathology
Pneumoperitoneum, Artificial / adverse effects*,  methods
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7440-37-1/Argon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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